"We suspect that their cells are still producing protein, but that the balance is somewhat disrupted. In any case, we found that these people have a poorer prognosis than multiple myeloma patients with an intact ribosome."
The professor added: "A few years ago, we discovered defects in the ribosome of patients with acute lymphatic leukaemia. Now we know that the same applies to multiple myeloma.
"In all likelihood, this will also hold true for other types of cancer. Our next research goal is finding out for which cancers this is the case, how the link between ribosome and proteasome works, and what the possibilities are of drugs that target the ribosome itself."
Source: Leukemia 2 December 2016; doi: 10.1038/leu.2016.370
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