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Transplacental haemorrhage (TPH) may occur following a sensitisng event during pregnancy or at delivery and can lead to RhD immunisation. Assessment of TPH is an important element in determining the amount of anti-D to be administered to a RhD-negative mother following a sensitising event or after delivery of an RhD-positive infant.

The joint Consensus Conference of the Royal College of Physicians of Edinburgh/Royal College of Obstetricians and Gynaecologists on anti-D prophylaxis stated that 1–2% of RhD-negative pregnant women at risk still become sensitised.

This guideline is an updated version of the guideline published in Feb 2009. 

This guideline has an update please see the information below.

Declaration of Interests

The BSH paid the expenses incurred during the writing of this guidance. None of the authors had conflicts of interest to declare. All authors have made a declaration of interests to the BSH and Task Force Chairs which may be viewed on request.