19 February 2020

A major US project aimed at finding improved treatments for children with relapsed acute leukaemia is being extended into Europe.

The US-based Leukemia and Lymphoma Society have developed the LLS PedAL clinical trial, with the aim of testing targeted therapies for high-risk leukaemias. It forms part of a $100 million initiative by the charity to tackle children’s cancers.

Earlier this month, the chairs of the LLS PedAL trial set out their plans at the 8th ACCELERATE Paediatric Oncology conference in Brussels.

Professor Christian Michel Zwaan, of Princes Maxima Hospital in Utrecht, Netherlands, and Dr Dirk Reinhart, director of paediatric oncology at the University Hospital in Essen, Germany, are working with the charity on the European end of the project. They are forming a European AML consortium, to ensure as many children from Europe as possible have access to the trial when it launches later this year.

The Leukemia and Lymphoma Society says: “This trial, which will test targeted therapies in children with acute myeloid leukaemia, and eventually other high-risk leukaemias, will benefit not only children in the United States, but in several European countries, as well as the UK, Australia, New Zealand and Canada.

“We anticipate opening the trial in approximately 200 sites around the US, Canada and across the globe.”

Source: Leukemia and Lymphoma Society


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