28 April 2022

Scientists have identified a possible new method of halting the progression of lymphoma.

Professor Ai Kotani of Tokai University School of Medicine in Japan, and colleagues investigated the activity of extracellular vesicles (EVs). These are particles released by cells that transport proteins and nucleic acids, and those that are released by cancer cells aid tumour survival.

In tests on mice, the team found that the tumour-supporting action of EVs in lymphoma is boosted by the presence of an enzyme which breaks down lipids in the EV membrane.

The breakdown of EV membrane lipids by 'secreted phospholipase A2' (sPLA2) increases the production of fatty acids and cytokines, among other substances, which allow greater tumour growth.

Inhibiting sPLA2 with a drug suppressed lymphoma growth in mice. In addition, studies on samples from patients with large B cell lymphomas showed that higher levels of sPLA2 were linked to lower survival.

“Overall, the sPLA2-mediated EV modification promotes tumour development,” the authors write.

They add that this sPLA2-EV axis “will become a new drug target for cancer treatment as a new immune checkpoint”.

“In addition,” they believe, “sPLA2 may enhance the inherent abilities of various types of extracellular vesicles, such as those with tissue protecting and anti-inflammatory effects.”

Source: Kudo K, Miki Y, Carreras J, Nakayama S, Nakamoto Y, Ito M, Nagashima E, Yamamoto K, Higuchi H, Morita SY, Inoue A, Aoki J, Ando K, Nakamura N, Murakami M, Kotani A. (2022) “Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma.” Cell Metabolism, doi: 10.1016/j.cmet.2022.02.011

Link: https://www.sciencedirect.com/science/article/abs/pii/S1550413122000833

Disclaimer: The news stories shared on this site are used as a way to inform our members and followers of updates and relevant information happening in Haematology. The BSH does not endorse the content of news items from external sources, and is not in a position to verify the findings, accuracy or the source of any studies mentioned. Any medical or drugs information is provided as an information resource only, and is not to be relied on for any diagnostic or treatment purposes.

News service provided by Englemed News.