This is a comprehensive but pragmatic new guideline and focuses on the accurate diagnosis, delineation of severity types and subsequent management of this rare haematological condition.
The guideline emphasises the importance at the diagnostic stage of considering and testing for inherited bone marrow failure syndromes such as Fanconis anaemia and dyskeratosis congenita, as it is increasingly recognised that patients may present in adulthood with few or no somatic features. There is a comprehensive table with recommended baseline investigations, bone marrow findings and alternative diagnoses to consider which may be confused with aplastic anaemia.
Treatment is divided into supportive and specific, the latter providing up to date recommendations for immunosuppressive treatment and who should be considered for allogeneic stem cell transplantation. A treatment algorithm is provided and advice regarding timing of donor searches.
Pragmatic definitions are provided for treatment responses and outcomes and finally there are separate concise sections on management in pregnancy , of the more frail and elderly patient and the relationship between paroxysmal nocturnal haemoglobinuria and aplastic anaemia at diagnosis and more generally.
Please note this guideline is corrected by an Errata Corrigendum; link for which can be found on the online published guideline.
Declaration of Interests
The BSH paid the expenses incurred during the writing of this guidance. None of the authors had conflicts of interest to declare. All authors have made a declaration of interests to the BSH and Task Force Chairs which may be viewed on request.