Mantle cell lymphoma (MCL) is a B cell malignancy with unique biological, pathological and clinical features comprising 310% of all non-Hodgkin lymphomas (NHLs) (Swerd-low et al, 1983). It was recognised as a specific entity in the revised European-American classification of lymphoid neo-plasms (REAL) classification (Harris et al, 1994) and is characterized by the chromosomal translocation t(11;14)(q13-3;q32-33), resulting in over-expression of the cell cycle protein cyclin D1 (Akiyama et al, 1994; Campo et al, 1999).
Simon Rule Audio Commentary - Length: 8 Minutes 58 Seconds

Declaration of Interests

The BSH paid the expenses incurred during the writing of this guidance. None of the authors had conflicts of interest to declare. All authors have made a declaration of interests to the BSH and Task Force Chairs which may be viewed on request.