Fresh frozen plasma (FFP) is given primarily for three indications: to prevent bleeding (prophylaxis), stop bleeding (therapeutic) or for plasma exchange. Prophylactic transfusions are mainly used prior to surgery or invasive procedures. Many possible indications in patients without major bleeding are not substantiated by robust trial data.

Declaration of Interests

The BSH paid the expenses incurred during the writing of this guidance. None of the authors had conflicts of interest to declare. All authors have made a declaration of interests to the BSH and Task Force Chairs which may be viewed on request.