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• New AML genes discovered

• 2017 Clinical Excellence Awards Round

• Applications open to become the next BSH Student Representative

• Participate in the national Blood Transfusion and Blood Donation Survey

• RCP publish Future Hospital Programme report

• Applications invited for the position of Editor-in-Chief British Journal of Haematology

• Register now and save up to £150

• Abstract submissions for the BSH Annual Scientific Meeting 2018

• A HaemSTAR is born

• Survey reveals current UK practice of managing Hodgkin’s lymphoma in older patients

• Applications open for L'Oreal-UNESCO Women in Science Awards

• Digital digest

• Ibrutinib non-responders may benefit from combination therapy for CLL

• Digital digest - 2 February

• HSF1 blockers promising for multiple myeloma

• DNA repair and packaging genes linked to multiple myeloma risk

• BSH Blood Transfusion Guidelines used in NBTC Blood Components App

• Digital digest - 9 February

• Ageing immune system ‘key to cancer development risk’

• Hybrid-capture sequencing backed for lymphoid cancer

• Digital digest - 16 February

• Latest radiotherapy device will fine-tune bone marrow irradiation

• BSH member Dr Amit Sud awarded haematology research medal

• Progress predicted in haemoglobin disorder care

• Landmark CAR T-cell study results published

• Warning over anticoagulant use for atrial fibrillation in CKD

• Digital digest - 23 February

• Imaging tools reveals inner structure of red blood cells

• Celebrating Success: BSH member part of haematology department awarded Myeloma UK service award

• Promise for novel treatment in severe bleeding disorder

• Digital Digest - 2 March

• Age does not affect NHL survival after HCT

• STAT5 inhibitor could target oncogenic pathway in leukaemia

• Increased heart failure risk for breast cancer and lymphoma patients

• Mixed-phenotype acute leukaemia patients benefit from less toxic therapy

• International women's day 2018: Meet some of our women members making a difference in haematology

• Digital Digest - 20 April

• Former BSH President Allan Victor Hoffbrand wins Sultan Bin Khalifa International Thalassemia Grand International Award

• Cardiovascular risks faced by child cancer survivors

• Clue to future ALL relapse

• Headway in development of lymphoma epigenetics therapeutics

• BSH becomes sponsor and partner of Health Volunteers Overseas

• Stored blood ‘less safe’ for some patients

• Warning as blood stocks stay low

• BSH announces Professor Simon Rule as new Vice President

• Scientists get stem cells through... the snow

• Rare disease patients need Europe - MPs

• Applications are now open for NHS England’s Clinical Entrepreneurs Programme

• New therapeutic targets for aggressive diffuse large B-cell lymphoma

• Warfarin alternatives effective for catheter ablation

• Anaemia risks maternal death

• Applications open for Chief Scientific Officer's Knowledge Transfer Partnership programme for leaders in healthcare science

• Annual Scientific Meeting - Join the social media campaign

• New VTE prevention guidance for over-16s

• Professor John Barrett MD appointed as Editor-in-Chief of British Journal of Haematology

• Genetic variation and biomarkers may help predict brain injury risk in paediatric ALL

• Gene fusion an early event in childhood leukaemia

• Chronic graft-versus-host disease gene regulation insight

• ‘Organic gene therapy’ approach suggested for red cell disorders

• New cancer drug class unveiled at Imperial

• Genetic alterations in multiple myeloma revealed

• Novel epigenetic link to blood cancer

• NHS genomics project “at risk” - MPs

• BSH announces Professor Cheng-Hock Toh as President

• Special Resolution to adopt updated articles

• Digital Digest - 11 May

• Bloodwise Highlights from the BSH Annual Scientific Meeting 2018

• NHS preparing to offer CAR-T therapy to patients

• ‘Young, Black and Stigmatised’ - Dr Sonia Wolf wins inaugural Crucible Prize

• Progress towards universal red cell source

• Meta-analysis reveals best treatments for post-partum haemorrhage

• The Aplastic Anaemia Trust are inviting grant applications as they launch new research strategy

• Genetic profiling of blood samples could help personalise multiple myeloma treatment

• Genomic analysis could help patients with DLBCL

• Type O blood ‘increases risk of death from trauma’

• World Thalassaemia Day – Time of new hope?

• BSH celebrating International Nurses Day 2018

• Introducing Professor Cheng-Hock Toh - BSH President's first message

• Step towards biomarker that predicts CAR T cell therapy response

• Senior haematologists have called on NHS England to reverse restrictions on using ibrutinib to treat relapsed chronic lymphocytic leukaemia

• CPD budget cuts affecting nursing skills - Royal College of Nursing

• Tablet hope for cancer-related VTE

• Genome sequencing allows improved blood transfusion matching

• Inflammatory signalling protein plays key role in AML

• Haemophilia survey highlights fears

• ALL gene-environment interaction points to hygiene factor

• How haemophilia nursing care is evolving

• European trial of new leukaemia drug pairing

• Reprogrammed cells could correct haemophilia B

• Genomic atlas of human plasma proteome unveiled

• BSH celebrate World Blood Donor Day 2018

• Chief Executive of the Sickle Cell Society is awarded an OBE in the Queen’s Birthday Honours.

• Bone marrow recreated in lab

• Gene editing of healthy cells offers prospect for CAR T treatment of AML

• World Sickle Cell Day - Dr Sonia Wolf Q&A

• What is Sickle Cell Disease (SCD)?

• Football key to blood donor recruitment

• New target to fight Fanconi anaemia

• GP urgent cancer referrals increase sharply

• Message from BSH President

• Lymphoma risk from myelofibrosis treatment

• Blood cancer therapy toxicity examined

• New drugs are improving survival times for patients with aggressive type of blood cancer

• BSH Celebrating 70 years of the NHS

• Sepsis research targets vascular leakage

• New drugs improve MCL patient survival times

• Leukaemia virus changes DNA packaging

• DOACs a safe alternative to warfarin

• EMA approves CAR T-cell therapies in milestone decision

• Former BSH President Dr Patrick Carrington interviewed on BBC 5 Live for NHS 70th Anniversary

• Contaminated blood inquiry truth promise

• Gene therapy hope for Hunter syndrome

• Genetic changes in blood predict AML risk

• Biomedical science day 2018 - Meet BSH Member Dr Maria Teresa Esposito

• AML cell study offers clues to super-drug improvement

• Off-target effects dash gene editing hopes

• Genetics of Xga blood group system uncovered

• Urine test useful for monoclonal gammopathy

• A message from BSH President, Professor Cheng-Hock Toh

• BSH President Professor Cheng-Hock Toh elected as Academic Vice President of the RCP

• Blood cancers taking longer to be diagnosed than other cancers

• Study informs on monosomy 7 genetics

• Fertility risk for sickle cell and chemotherapy patients

• Knife crime surge draws on blood stocks

• Urgent appeal for Ro blood donors

• BSH expanding Early Stage Research Start-Up programme

• Leukaemia patients spared repeat chemotherapy following NHS review

• Shot Report 2017 published

• Obituary - Dr S. Mitchell Lewis

• Former BSH President Dr Victor Hoffbrand receives Wallace H. Coulter Award for Lifetime Achievement in Haematology

• Computational platform developed for multiple myeloma treatment

• Simple blood test could detect Multiple Myeloma

• Novel targets for mixed lineage leukaemia

• Patients perplexed by blood cancer diagnosis

• Brexit blood product plans revealed

• Tributes to campaigner who became nurse

• Blood cancer patients could be denied life-saving CAR-T therapy

• A message from BSH President, Professor Cheng-Hock Toh - August 2018

• Blood cancer awareness - Meet BSH Member Graham Collins

• Celebrating NHS 70 and Haematology

• Blood test predicts lymphoma therapy success

• Enzymes may enable type O blood transformation

• CAR-T backed for NHS

• “Achilles’ heel” of anaplastic large-cell lymphoma identified

• Study discovers ten times more haematopoietic stem cells than previously thought

• Study reveals the impact on the brain of chemotherapy for acute lymphoblastic leukaemia

• Comment: Dr Maria Esposito on NHS decision to approve use of CAR T therapy

• AI to improve platelet supply

• Genomics focus: Meet BSH Member David Rees

• European collaboration for cancer research

• CAR-T therapy provisionally rejected for adult B-cell lymphoma

• Office Closure & Temporary Office Move

• ASM 2019: Call for abstract reviewers

• Changes to BSH Membership from 2019

• Immediate compression may reduce risk of long-term DVT complications

• A message from BSH President, Professor Cheng-Hock Toh - September 2018

• Paediatric radiotherapy guidance updated for new technologies

• Lung cancer drugs studied for leukaemia treatment

• BSH Student Essay Prize 2018

• Inquiry searches for undiagnosed blood contamination victims

• Apply for the 2019 Healthcare Science Awards

• Dan's Story: BSH member inspires patient to follow career in medicine

• CAR-T deal allows adult lymphoma treatment

• May’s SOS for cancer care

• Leukaemia UK launch 'Future of Haematology' Grants Programme

• Hope for fewer blood transfusions for myelodysplasia care

• World Thrombosis Day 2018 - Message from BSH President Professor Cheng-Hock Toh

• World Thrombosis Day: Meet BSH Member & Thrombosis expert Professor Beverley Hunt

• World Thrombosis Day: Thrombosis UK offer range of resources, grants and educational opportunities

• New prognostic tool provides “step change” in myeloproliferative neoplasm care

• Blood and organ donors from black communities needed

• Genetics-based prognostic tool developed for myelodysplastic syndrome

• NIHR-BSH Researcher of the Year Award scheme 2019

• Massive new AML dataset published

• BSH & Wiley renew partnership to publish British Journal of Haematology

• New technique revealed to help blood cells regenerate

• A message from BSH President, Professor Cheng-Hock Toh - October 2018

• Duvelisib hope for hard-to-treat CLL and SLL

• BSH Crucible Prize: Feature with 2018 winner Dr Sonia Wolf

• ‘Rethink’ needed for classification of VTE

• Relapsed AML returns in ‘stealth mode’

• National Pathology Week - Meet BSH Member Dr Sheila O'Connor

• Low-fat diet might benefit obese children with ALL

• Denosumab effective for osteoporosis in transfusion-dependent thalassaemia

• Chemotherapy and immunotherapy success in AML study

• Top 10 research priorities for living with and beyond cancer announced

• AML gene study brings personalised medicine one step closer

• Discount deal makes CAR-T available to young leukaemia patients

• Multiple myeloma drug hope

• A message from BSH President, Professor Cheng-Hock Toh - November 2018

• ‘Universal plasma’ filtration plans unveiled

• SCID study identifies factors influencing survival

• BSH to offer EHA Travel Grants

• CRISPR therapy feasible for foetal haemoglobin reactivation

• BSH Communications Committee Vacancy

• Fred Hutchinson researchers present latest on CAR-T cell therapy at ASH 2018

• Chance discovery could revolutionise platelet donations

• Paediatric CAR-T therapy begins in England

• BSH President Professor Cheng Hock Toh pays tribute to outgoing Editor of BJHaem, Professor Finbarr Cotter

• Sickle cell gene therapy success

• New tool to identify aggressive lymphomas

• Differences between paediatric and adult AML uncovered

• CAR T-cell therapy approved for more NHS treatment

• CRISPR accuracy breakthrough

• A message from BSH President, Professor Cheng-Hock Toh - December 2018

• Obituary - Professor Sir David Weatherall

• Lenalidomide extends remission in newly-diagnosed myeloma

• Eye drop treatment offers AML hope

• Human skin cells turned into blood stem cells

• First European CAR T cell meeting announced

• Boosted cord blood aids transplant

• Haematology Nursing: Meet BSH Member Bethan Ingram

• AZD8055 promise for CLL combination treatment

• Comments needed for ASH VTE Guideline Treatment of Acute VTE

• NHS plan offers new hope for blood cancer care

• Blood screening for Zika ‘not cost‑effective’

• CRISPR gene editing library identifies new immune regulators

• Infected Blood Inquiry

• Venetoclax fast-tracked into NHS for CLL

• Ibrutinib effective for CLL therapy

• New genetic classification of B-ALL

• ‘Twin genes’ behind B-cell disease are not identical

• World Thrombosis Day Campaign Appoints BSH member Beverley Hunt as New Steering Committee Chair

• A message from BSH President, Professor Cheng-Hock Toh - January 2019

• Delays in blood cancer diagnosis could be avoided, Yorkshire study finds

• No benefit from transplantation in hypodiploid ALL for children and young people, study finds

• Leukaemia causes bone marrow cells to age prematurely

• NICE recommends new CAR-T cell therapy for DLBCL

• BSH grant recipient has work published in Oncogene

• Tissue homing of T cells revealed

• Hope for new drugs for relapsed AML

• CAR‑T therapy rejected for DLBCL in Scotland

• Antibody could prepare for stem cell transplant

• Sickle cell silent strokes studied

• Obituary - Dr Bryon Roberts (1933 - 2019)

• Vitamin D and immune cells stimulate myelofibrosis in MPN

• BSH gathering UK Clinical Haematology Workforce data

• BSH partnering with HVO to offer short term overseas placements for UK Haematologists

• BSH and Wiley partner on a peer-reviewed open access journal

• A message from BSH President, Professor Cheng-Hock Toh - February 2019

• ‘Invisible’ stem cells offer new transplant prospects

• Roger Counter Foundation to support BSH Research Grants

• Role of free radicals in blood clotting revealed

• Patient involvement partnership sets priorities for rare inherited anaemias

• Thromboprophylaxis study shows limited benefits for cancer patients

• Telomere test for CLL

• International women's day 2019: Meet some of our women members making a difference in haematology

• Second patient achieves full HIV remission after stem cell therapy

• Vitamin analogue may boost stem cell transplant

• AML cell type atlas created

• Daratumumab combination therapy approved for relapsed multiple myeloma

• Half-matched transplant success for sickle cell and thalassaemia

• Two-minute test to assess platelet function developed

• BSH Ordinary Trustee election results

• Contradictory role for protein in AML uncovered

• BSH Annual Scientific Meeting 2019 - Join the social media campaign

• A message from BSH President, Professor Cheng-Hock Toh - March 2019

• Chronic oncologist shortages revealed

• New study reveals how mistakes in antibody production may trigger ALL

• General Haem Task Force Vacancy

• Deformable blood stem cells could help transplant procedures

• Drug combination gives hope to older AML patients

• Surprising role for protein in GvHD

• Live imaging shows CAR-T therapy killing lymphoma cells

• New sub groups of acute erythroid leukaemia defined

• Gilteritinib improves FLT3-mutated AML survival

• Successful gene therapy for SCID in infants

• Cancer genetic vulnerabilities revealed on a large scale using CAS-9 knock out screens

• Prophylactic Factor VIIa therapy tested for haemophilia

• Old diabetes drug shows promise for preventing lymphoma

• Professor Victor Hoffbrand receives BSH Lifetime Achievement Award

• New promising target for AML discovered

• Gene therapy may outperform stem cell transplant for beta-thalassaemia

• Grant Impact report: Dr Yeong Jer Lim, ASH Travel Scholarship, 2018

• High-risk multiple myeloma DNA marker identified

• Grant Impact report: Dr George Adams, ASH Travel Scholarship, 2018

• New study paves the way for B cell therapy

• Single-cell analysis of bone marrow microenvironment cells completed

• Spliceosome could hold key to stopping AML progression

• ‘Powerful’ APL drug combination could benefit AML patients

• New drug can tackle ibrutinib resistance in MCL patients

• Experts call for SCD screening for migrants in Europe

• New molecule driving Hodgkin’s lymphoma growth discovered

• Grant Impact report: Katie Parrott, Student Elective Scholarship 2018

• Genetic variations may affect sickle cell trait athletes’ risk of collapse

• Meet Huw Rowswell - NIHR / BSH Nursing Award Winner

• Lenolidomide approved by NICE for treatment of multiple myeloma

• A message from BSH President, Professor Cheng-Hock Toh - May 2019

• Neurotoxic side-effects of CAR T-cell therapy revealed

• Wnt signalling study brings lab-made stem cells closer

• New culture technique could increase access to stem cell transplants

• New target for B-cell lymphoma identified

• 'Antimicrobial resistance: Biting the hand that feeds' - Dr Jennifer Darlow wins Crucible Prize

• New avenue for targeted therapy for T-cell leukaemia

• Measuring walking speed aids prognosis of elderly cancer patients

• Triple therapy boosts B-cell lymphoma treatment

• New haemophilia gene therapy to help young patients

• Grant Impact report: Thea Chandler, Student Elective Scholarship 2018

• Grant Impact report: Eilish McKenna, Student Elective Scholarship 2018

• Sickle Cell Disease in Childhood: Standards for Clinical Care Consultation

• Pregnancy history of blood donors does not affect recipient mortality risk

• World Sickle Cell Day 2019 - Dr Banu Kaya explains the advances made in the understanding and treatment of SCD

• Hope for non-invasive prenatal sickle test

• AML researcher receives Cancer Research UK fellowship grant

• NHS prepares for new generation of ‘agnostic’ cancer drugs

• Promising early results for novel sickle cell drug

• BSH Global Haem SIG seeking Task Force volunteer for Plenary Speaker Scheme

• Stress-responsive protein’s role in CML revealed

• A message from BSH President, Professor Cheng-Hock Toh - June 2019

• Myeloma leads the way in cancer survival improvements

• Bleeding and thromboembolic risks for blood cancer patients estimated

• Immunotherapy hope for paediatric ALL treatment

• Dasatinib ‘pauses’ CAR T cell therapy activity

• Depression linked to early death in blood cancer patients

• Down's syndrome leukaemia genes pinpointed

• Rise predicted in B-cell non-Hodgkin’s lymphoma cases

• CAR-T cell therapy ‘super-charged’ for solid tumours

• Cure Leukaemia Announce 12 Funded Centres Across The UK

• Rise expected in haemophilia A and B market

• Leukaemia stem cell study reveals cause of immune evasion

• Effects of iron status on health studied

• Physician Associate Focus - Meet BSH Member Jamie Saunders

• BRCA2 mutations linked to childhood lymphoma

• A message from BSH President, Professor Cheng-Hock Toh - July 2019

• Antibiotics could be used to treat CTCL

• New drug target identified for primary effusion lymphoma

• Combination therapy shows early success in CLL trial

• BSH/NHSE Acute Oncology Services Survey

• Hope for new lymphoma ‘immunotransplant’ therapy approach

• Mature AML cells can regain stem cell properties

• Combination therapy for treatment-resistant ALL studied

• Newly launched Haematology Podcast sees early success

• Link between anaemia and necrotising enterocolitis studied

• Guidelines Session ASM videos available for viewing

• BSH seeks Consultant to join Communications Committee

• New gene editing technique tested in lymphoma cells

• Global Haematology SIG London Workshop

• BSH seeks volunteer Chair for Genomics Working Group

• NIHR-BSH Researcher of the Year Award

• Access to haemophilia drug emicizumab widened

• A message from BSH President, Professor Cheng-Hock Toh - August 2019

• BSH Rebuttal to NICE NG89 Recommendations

• Selinexor shows promise for refractory multiple myeloma

• Red blood cell line may revolutionise malaria research

• AML drug may be key to cancer immunotherapy

• Heart risk after childhood cancer studied

• New guidelines on rare aggressive T-PLL

• Concern about blood cancer diagnosis progress

• Use of haematopoietic stem cell transplantation for sickle cell disease for adults.

• NHS England Evidence review: Comments needed on for delayed haemolytic transfusion reactions and hyperhaemolysis in patients with haemoglobinopathies

• Three times more men with haemophilia than previously thought

• Genomics Focus: Meet Dr Suthesh Sivapalaratnam

• New potential targets for lymphoma treatment discovered

• Radiotherapy could help prevent CAR-T cell therapy side effects

• Scientists discover how lymphoma cells metastasise to the CNS

• Arthritis drug could reduce MPN symptoms

• Gene test reveals new option for JMML

• A message from BSH President, Professor Cheng-Hock Toh - September 2019

• Familial risk of blood cancers analysed

• BSH Global Haematology SIG: We are looking for a Lab Scientist and Paediatric Haematologist for one week trip to Zambia

• Laser technology cuts blood incubation time

• Few sickle cell trials cross borders

• New combination treatment suggested for AML

• Hypertension warning for ibrutinib

• Research starts on preventing cognitive decline in paediatric ALL patients

• Debate rages over human germline editing

• Studies highlight RNA splicing faults in cancer formation

• Viagra potential for bone marrow mobilisation

• Charity calls for an end to delays in blood cancer diagnosis

• Collaboration to boost care of childhood cancer in developing world

• Professor Andrew M. Evens appointed as Editor-in-Chief of British Society for Haematology (BSH)’s new Open Access journal eJHaem

• Link between cognitive problems and fitness for ALL survivors

• Improvements to cancer immunotherapy unveiled

• Plant compound could improve gene therapy

• ‘Prime editing’ system could efficiently correct DNA in human cells

• A message from BSH President, Professor Cheng-Hock Toh - October 2019

• Board of Trustee Nominations

• Hospital visit patterns could identify potential myeloma risk

• Treating ‘smouldering’ multiple myeloma delays progression

• Trial reduces central nervous system relapse in ALL

• New wave of embryonic haematopoiesis discovered

• Antibiotics could overcome venetoclax resistance in AML

• CRISPR-edited immune cells for cancer tested in Phase I trial

• ASH-BSH Abstract Achievement Award winners announced

• BSH President's November message

• Immunotherapy study identifies multiple myeloma neoantigens

• Hydroxyurea may prevent cytarabine resistance in AML

• Bone marrow transplant survival rate rises

• Progress for Philadelphia chromosome ALL treatment

• Join the Teenage and Young Adult Special Interest Group

• A look at the complexities and challenges in Lymphoma and the work of the BSH Lymphoma SIG on World Cancer Day Feb 4th 2020

• Cutaneous T-cell lymphoma origins revealed

• Defect drives primary resistance to CAR-T cell therapy

• Gene therapy success for X-CGD patients

• International Day of Women & Girls in Science 2020: An Interview with Professor Adele Fielding

• Single gene cluster loss associated with multiple myeloma

• Aplastic Anaemia Awareness Day 2020

• Blood Clot Awareness Month 2020: Blood Clot Management at University Hospitals Plymouth

• International Women’s Day 2020 – Interview with Dr. Tamara Everington

• COVID-19 Updates

• BSH cancels 2020 Annual Scientific Meeting

• Charity issues coronavirus guidance for blood cancer patients

• Genes identify ‘ultra-high risk’ multiple myeloma

• BSH and COVID-19

• NIHR Appoints Dr Dan Hart as National Specialty Lead for Haematology

• Professor Toh's 24th and final message to BSH: #bettertogether

• Announcement of new trustees

• Introducing Professor Adele Fielding - BSH Presidents first message

• COVID 19 causes new clotting disorder – Dublin study

• NHSBT - Understanding the convalescent plasma trials for COVID-19

• A message from BSH President, Professor Adele Fielding - May 2020

• Novel AML model offers new target

• Child shielding rules relaxed - but not for some blood cancer patients

• Obituary - Professor Dennis Wright

• Trial results support use of early prophylaxis for childhood haemophilia A

• A message from BSH President, Professor Adele Fielding - June 2020

• Immune landscape of haematological cancers mapped

• A message from BSH President, Professor Adele Fielding - July 2020

• BSH Member Research – we need your help

• A message from BSH President, Professor Adele Fielding - August 2020

• Medical marijuana for sickle cell patients means fewer hospitalisations

• Guidelines on the use of irradiated blood components published on 18 August 2020

• Blood transfusions could protect brain after stroke

• A message from BSH President, Professor Adele Fielding - September 2020

• Leukaemia nervous system “sanctuary” discovered

• What is a virtual poster walk?

• A message from BSH President, Professor Adele Fielding - October 2020

• Blood group linked to COVID-19 risk

• India trial finds limited effectiveness from convalescent plasma

• New way to test drugs for children’s cancers

• BSH Crucible Prize: Interview with 2020 winner Dr Joshua Bomsztyk

• Board of Trustee Nominations 2020

• A message from BSH President, Professor Adele Fielding - November 2020

• Transplant proves beneficial for older myelodysplastic syndrome patients

• No increased COVID-19 risk for children with cancer

• COVID-19 thrombosis clarity to improve research

• A message from BSH President, Professor Adele Fielding - December 2020

• Myeloproliferative neoplasm mutations can occur decades before cancer develops

• No benefit from increased haemoglobin threshold for very premature babies

• Cord stem cell hope for severe COVID-19

• On-off 'switches' to control CAR-T cell activity

• Variation in cancer patient COVID-19 responses

• New global clinical guidelines for von Willebrand Disease

• Scientists identify possible therapeutic approach to overcome AML drug resistance

• COVID-19 convalescent plasma collection halted after fresh setback

• A message from BSH President, Professor Adele Fielding - January 2021

• A message from BSH President, Professor Adele Fielding - February 2021

• A message from BSH President, Professor Adele Fielding - March 2021

• Cancer patients may need rapid COVID-19 vaccine booster, early study suggests

• Single-cell genetic testing method identifies cancer stem cells

• Whole genome sequencing role in guiding blood cancer treatment

• Mechanism shared by sickle cell disease and malaria resistance revealed

• Guidance produced by the Expert Haematology Panel (EHP) focussed on Vaccine induced Thrombosis and Thrombocytopenia (VITT)

• Promising dual CAR-T therapy for B-cell lymphoma

• New group launched to fund research into Covid-19 vaccine efficacy for blood cancer

• A message from BSH President, Professor Adele Fielding - April 2021

• Information theory used to find ALL driver gene

• Potential key to preventing haemophilia therapy inhibitors

• COVID-19 vaccine offers hope for myeloma patients

• Treatment hope for sickle cell disease

• New Scandinavian study of Oxford COVID vaccine thrombosis risk

• New osteoporosis guidance for stem cell recipients

• Group of charities announce first blood cancer vaccine efficacy research funding

• A message from BSH President, Professor Adele Fielding - May 2021

• Immunocompromised patients mount T-cell response to SARS-CoV-2 infection

• Success for gene therapy for child immunodeficiency

• New blood group link to COVID risk

• Novel NK cell therapy for lymphoma ‘promising’

• New drug approved for two rare blood disorders

• Successful treatment of COVID-19 vaccine-associated thrombosis

• Charity collaborative announces investment of £800K in vaccine efficacy research

• Study of bone marrow suppression in acute myeloid leukaemia

• Ischaemic stroke linked to COVID-19 vaccine

• Stem cell memory T-cells’ role in CAR T therapy for childhood leukaemia

• Childhood therapy-related leukaemia risk studied

• New delivery system to limit tPA side effects

• Proof-of-concept treatment developed for haemoglobin disorders

• Combination therapy hope for CLL patients

• COVID vaccine’s rare link to low platelet count

• Treatment identified for COVID-19 vaccine clots

• Keeping patients with leukaemia safe during the pandemic

• Acalabrutinib gets further approval in Scotland for CLL

• Researchers investigate blood clotting in COVID-19 patients

• Plasma treatment could improve COVID-19 survival in blood cancer patients

• Blood test can detect multiple cancers in people at high risk

• Potential new drug for mantle cell lymphoma

• A message from BSH President, Professor Adele Fielding - June 2021

• Lockdown ending poses multiple risks for blood cancer patients

• Breakthrough in understanding of process leading to pulmonary embolism

• Myeloma patients’ varied response to COVID-19 vaccines

• Rapid testing key to countering vaccine blood clot risk

• Mechanism behind rare COVID vaccine reaction revealed

• New target to prevent leukaemia in Down’s syndrome children

• Sickle cell risk factors for severe COVID-19 identified

• New insights into post-chemotherapy blood recovery

• Gene test could prevent unnecessary bone marrow biopsy

• New potential target to slow down follicular lymphoma

• Adenoviral vaccines may give long-term immune boost

• Cancer patients benefit from remote 24-hour monitoring

• Thiopurines can cause mutations that lead to ALL relapse

• A message from BSH President, Professor Adele Fielding - July 2021

• Abnormal antibody response behind severe COVID-19 blood clots

• Comprehensive genome sequencing guides child cancer therapy

• NICE issues rapid guideline for vaccine induced blood clots

• New target could help treat aggressive cancers

• Heparin beneficial in non-critical COVID care

• New genetic test developed for lymphoid neoplasms

• Iron chelators show promise against AML cell line

• High mortality rate of vaccine-induced thrombocytopenia and thrombosis

• Outcomes in child AML linked to mutational burden

• Increased blood clotting linked to ‘long COVID’

• Mastocytosis treatment approved for NHS

• Newly identified T cell profiles could benefit COVID-19 treatment

• In memory of Dr Maria Helena Gilleece MD

• COVID-19 infection much more likely to causes blood clots than vaccines – major analysis

• Trial of booster vaccine for immunocompromised patients

• COVID-19 exposure raises surgery risk

• New mechanism of blood clotting during inflammation identified

• How ageing blood could predict risk of blood cancer

• CRISPR screening identifies new AML target

• Platelets cause blood vessel damage in COVID-19 patients

• Novel drug offers hope for aggressive B-cell lymphoma

• Ganciclovir may cause DNA mutations after stem cell transplant

• Promising vaccine results in stem cell recipients

• Applications open for stem cell transplant research grants

• Deep vein thrombosis diagnosed using artificial intelligence

• How chemotherapy affects development of blood cells

• New targets identified for anaplastic large cell lymphoma

• AI-assisted diagnosis for blood cancers developed

• For a minute there I lost myself

• Study shows potential of antibody-drug conjugate for multiple myeloma therapy

• Potential non-invasive test for MALT lymphoma

• Hydroxyurea could reverse sickle cell-related heart abnormalities

• Sam Machin MB ChB FRCP FRCPath Obituary

• CAR-NK therapy for multiple myeloma developed

• New role for protein in AML identified

• New sickle cell disease treatment approved for NHS

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• Atypical lymphocyte in primary HIV infection

• Trephine biopsy in malignant melanoma

• Bone marrow aspirate in malignant melanoma

• Platelet aggregates, blood film

• Oxalosis, trephine biopsy section

• Intra-pelvic haemorrhage following trephine biopsy: CT scan of pelvis

• Paroxysmal nocturnal haemoglobinuria associated with haemophagocytic syndrome

• Gelatinous transformation

• Jordans' anomaly

• Cobra like macrophage in visceral leishmaniasis

• Bacilli in blood film

• Bacilli in blood film in pseudomonas septicemia

• Multiple mitochondria in normal and tumour cells

• Congenital Pelger–Huët anomaly

• Oral haematoma

• Histoplasma in peripheral blood neutrophil

• Burkitt-like cytology in biphenotypic acute leukaemia

• Burkitt-like cytology in biphenotypic acute leukaemia (1)

• Extreme neutrophil vacuolisation in sepsis

• Striking monocyte vacuolisation in sepsis

• Toxic granulation and striking vacuolisation of neutrophils in sepsis

• Intramonocytic malarial pigment

• Histoplasmosis in bone marrow

• Mycobacterium avium intracellulare infection in a patient with AIDS

• Mycobacterium avium intracellulare (MAI) on routine H&E stain of a bone marrow section from a patient with AIDS

• Diagnosis of systemic lupus erythematosus by bone marrow cytology

• LE cells in incubated bone marrow

• SLE diagnosed from bone marrow

• Metastatic malignant melanoma in bone marrow, MGG stain

• Metastatic malignant melanoma in bone marrow trephine biopsy section, immunohistochemistry, APAAP technique, with hmb45

• Toxic Granuation and Döhle bodies in a patient with severe bacterial infection

• Bone marrow sarcoidosis in a patient with diffuse large B-cell lymphoma

• Visceral leishmaniasis (2)

• Visceral leishmaniasis (3)

• Letterer-Siwe disease (1)

• Letterer-Siwe disease (2)

• Letterer-Siwe disease (3)

• Letterer-Siwe disease (4)

• Alveolar rhabdomyosarcoma infiltrating the bone marrow

• Bone marrow aspirate in Niemann-Pick disease

• Leishmaniasis

• Haemophagocytosis in probable typhoid fever (1)

• Haemophagocytosis in probable typhoid fever (2)

• Haemophagocytosis in probable typhoid fever (3)

• Haemophagocytosis in probable typhoid fever

• Probable granuloma in typhoid fever (1)

• Probable granuloma in typhoid fever (2)

• Döhle bodies and toxic granulation

• Endothelial cells, low power

• Endothelial cells, high power

• Binucleated lymphocytes

• Cytoplasmic fragments mistaken for malaria parasites (1)

• Cytoplasmic fragments mistaken for malaria parasites (2)

• Cytoplasmic fragments mistaken for malaria parasites (3)

• Haemosiderin in a plasma cell, May-Grünwald-Giemsa stain

• Tuberculous granulomas in a trephine biopsy section, low power

• Tuberculous granulomas in a trephine biopsy section, low power (ii)

• Tuberculous granulomas in a trephine biopsy section, high power

• Toxic granulation and left shift induced by G-CSF

• Nuclear dysplasia and Döhle body formation induced by G-CSF

• Neutrophil vacuolation induced by G-CSF

• Multiple Döhle bodies and nuclear dysplasia induced by G-CSF

• Döhle body and vacuolation induced by G-CSF

• Left shift, toxic granulation, Döhle bodies and nuclear dysplasia induced by G-CSF

• Dysplastic neutrophil with ring-shaped nucleus following G-CSF therapy

• Alder-Reilly anomaly in a neutrophil

• Alder-Reilly anomaly in two neutrophils

• Gasser cell (lymphocyte with heavy granules)

• Monocyte with heavy granules and vacuoles as the result of a mucopolysaccharidosis

• Neutrophil showing Alder-Reilly anomaly

• Lymphocyte in mucopolysaccharidosis

• Monocyte in mucopolysaccharidosis

• Carcinoma cells infiltrating bone marrow with reactive fibrosis

• Carcinoma cells infiltrating bone marrow (2) with reactive fibrosis

• Carcinoma cells in an imprint from a trephine biopsy section, low power

• Carcinoma cells in an imprint from a trephine biopsy section, high power

• PAS-block positivity suspected from a Romonowsky-stained film

• Buffy coat film showing a clump of carcinoma cells

• Sea-blue histiocyte

• Sea-blue histiocytes

• Melanonychia striata secondary to hydroxycarbamide

• Chemotherapy-induced dysplasia

• Leishman-Donovan bodies in the bone marrow

• Leishmaniasis (1)

• Cohesive epithelioid macrophages in a bone marrow aspirate indicating the presence of granulomas (low power)

• Cohesive epithelioid macrophages in a bone marrow aspirate indicating the presence of granulomas (high power)

• Histology of bone marrow granuloma, H& E, low power

• Histology of bone marrow granuloma, H& E, high power

• Erythroid island

• A Mott cell

• Haemophagocytosis in the bone marrow aspirate of a young woman with coeliac disease

• Gaucher disease discovered during pregnancy

• Normal bone marrow film, Jenner-Giemsa with phosphate buffer at pH 6.6

• Infection-related haemophagocytic lymphohistiocytosis (HLH) in a HIV stage 4 patient with Mycobacterium tuberculosis infection

• Neuroblastoma with neuropil

• Emperipolesis in a patient with RAEB-2

• Dural biopsy in extranodal Rosai-Dorfman disease, which radiologically and histologically mimicked meningioma (H& E)

• Dural biopsy in extranodal Rosai-Dorfman disease, which radiologically and histologically mimicked meningioma (immunohistochemistry for S-100)

• Fragmentation haemolysis secondary to sepsis in a three-month-old female infant

• Plasmacytoid lymphocyte (Tϋrk cell)

• Congenital hip dislocation in Fanconi anaemia, X-ray

• Howell-Jolly body-like neutrophil inclusion (1)

• Howell-Jolly body-like neutrophil inclusion (2)

• Monocytes ‒ yes, but monotony ‒ never!

• Haemophagocytic lymphohistiocytosis

• Reactive myelofibrosis in metastatic tumour of unknown origin

• Reactive myelofibrosis (reticulin stain) in a metastatic tumour of unknown origin

• Plasmodium falciparum gametocyte (i)

• Plasmodium falciparum gametocyte (ii)

• Reactive haemophagocytosis in a bone marrow aspirate

• The stages of mitosis

• Haemoglobin H disease

• Bone marrow metastatic involvement by penile squamous cell carcinoma

• Crystal-storing histiocytosis associated with plasma cell myeloma

• Neutrophils changed appearance with a new heart

• LD bodies with marrow plasmacytosis

• Tadpole in the marrow

• Large granular lymphocyte, blood film

• Perls' stain showing iron in macrophages

• Erythroid island with central macrophage

• Reactive lymphocytes in infection by Brucella spp (Brucellosis, also called undulant fever, or Malta fever)

• Disseminated metastatic prostatic carcinoma in a young male (1)

• Histoplasma in peripheral blood and bone marrow

• Howell-Jolly body-like inclusions in reactive myelocytes and metamyelocytes

• Non-immune haemolytic anaemia in a severe burns patient

• Mycobacterium avium intracellulare on bone marrow trephine

• Cryptococcus neoformans: Cerebrospinal fluid (CSF) cytospin and bone marrow trephine

• Immunobiology

• Lymphoid Malignancy

• Simultaneous diagnosis of precursor B-cell acute lymphoblastic leukaemia and chronic lymphocytic leukaemia, high power

• Neurolymphomatosis

• Anaplastic large cell lymphoma lymphoma

• Multiple myeloma 2, giant cell

• Syncytial neoplastic cells in paediatric Hodgkin lymphoma

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, H& E, low power

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, immunohistochemistry for CD30, low power

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, H& E, high power, 1

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, H& E, high power, 2

• Classical Reed-Sternberg cell in film of fine needle aspirate (Jenner-Giemsa stain)

• Lymph node biopsy in Hodgkin lymphoma

• Immunohistochemistry in Hodgkin's disease (Hodgkin lymphoma)

• Blood film of mantle cell lymphoma in evolution

• Paratrabecular infiltration in follicular lymphoma

• Diffuse large B-cell lymphoma

• Finger necrosis in cold agglutinin disease

• Type 1 cryoglobulinaemia in a patient with low grade non-Hodgkin lymphoma

• Rouleaux formation in lymphoplasmacytic lymphoma

• Splenic marginal zone lymphoma with peripheral blood lymphocyte clusters

• Diffuse large B-cell lymphoma in leukaemic phase

• Comparison of Ki67 positivity in mantle cell lymphoma (left) and in blastoid transformation (right)

• FDG-PET scan in cutaneous blastoid mantle cell lymphoma showing intense activity in a subcutaneous nodule

• Cold agglutinin in non-Hodgkin lymphoma

• Follicular lymphoma in leukaemic phase

• Marginal zone lymphoma of bone: MRI appearance

• Marginal zone lymphoma of bone: histology

• Marginal zone lymphoma of bone: immunohistochemistry

• PET/CT showing neurolymphomatosis as the presenting feature in a relapsed diffuse large B-cell lymphoma

• Bone marrow aspirate in primary diffuse large B-cell lymphoma of bone marrow (i)

• Bone marrow aspirate in primary bone marrow diffuse large B-cell lymphoma (ii)

• Hairy cell leukaemia

• Anaplastic large cell lymphoma, ALK-positive, in pleural fluid

• Ziehl-Neelsen (ZN) stain demonstrating acid-fast bacilli, identified as M. chelonae, which were the cause of vascular-catheter-related bacteraemia

• Anaplastic large T-cell lymphoma

• Primary cutaneous T-cell non-Hodgkin lymphoma on the shin completely healed following radiotherapy

• Skin infiltration in patient with adult T-cell leukaemia/lymphoma

• Primary cutaneous ALK-negative anaplastic large T-cell lymphoma

• Blood film in adult T-cell leukaemia/lymphoma

• Immunohistochemistry in subcutaneous panniculitis-like T-cell lymphoma

• Sézary cells

• Anaplastic large cell lymphoma overspill into peripheral blood

• Leukaemic phase of extranodal NK/T cell lymphoma of nasal type, peripheral blood film

• Anaplastic large cell lymphoma

• Peripheral blood in T-prolymphocytic leukaemia

• Hyperpigmentation and nodularity of skin in POEMS syndrome

• Circulating myeloma cell in a patient with refractory multiple myeloma

• Extramedullary myeloma

• Multiple myeloma cells in cerebrospinal fluid

• Extramedullary plasmacytoma of lung, haematoxylin and eosin

• Flaming plasma cell in IgA myeloma

• Pathological fracture of the proximal third of the shaft of the left humerus in multiple myeloma

• Cryoglobulinaemia

• CT scan of the pelvis in amyloidosis

• Plasmacytoma of the orbit in multiple myeloma, MRI scan (2)

• Plasmacytoma of orbit, histology following orbital biopsy: left, hematoxylin and eosin; right, immunohistochemistry for CD38

• Histology and immunohistochemistry of unusual skin lesions in multiple myeloma

• Bone marrow in multiple myeloma (1)

• Bone marrow in multiple myeloma (4): unusual cytoplasmic inclusions in myeloma cells

• Bone marrow in multiple myeloma (5): unusual cytoplasmic inclusions in myeloma cells

• Myeloma cells with crystals (i)

• Myeloma cells with crystals (ii)

• Myeloma cells with crystals (iii)

• Auer-rod like crystals in macrophages in myeloma (i)

• Auer rod-like crystals in macrophages in multiple myeloma (ii)

• Extramedullary plasmacytoma of the sphenoid sinus: T2 weighted MRI image

• Phagocytosis by myeloma cells

• Circulating plasma cells and rouleaux in plasma cell leukaemia

• Plasmablast in plasma cell leukaemia

• Auer-rod like inclusions in multiple myeloma

• Myeloma cells including a trinucleated cell containing Auer-rod-like inclusions

• Tissue biopsy section, multiple myeloma, haematoxylin and eosin

• Giant myeloma cells

• Giant binucleate myeloma cell

• Giant trinucleate myeloma cell

• Giant quadranucleate myeloma cell

• Neoplastic pleural effusion in refractory multiple myeloma

• Intracranial plasmacytoma causing bilateral sixth nerve palsy (1)

• Intracranial plasmacytoma causing bilateral sixth nerve palsy (2)

• Multinucleated tumour cell in multiple myeloma

• Multinucleated cell in multiple myeloma

• Multinucleated plasma cell in multiple myeloma

• Giant multinucleated tumour cells in multiple myeloma

• A giant multinucleated tumour cell in multiple myeloma

• Rouleaux formation and plasma cell - peripheral blood film of a patient with multiple myeloma

• Plasma cells in multiple myeloma - peripheral blood film

• Multiple myeloma 5, Dutcher body

• Multiple myeloma (1)

• Multiple myeloma (2)

• Multiple myeloma (3)

• Multiple myeloma (4)

• Multiple myeloma (5)

• Multiple Myeloma 1, Dutcher bodies

• Blood film in chronic lymphocytic leukaemia, mixed cell type

• CT scan showing a macronodular pattern of infiltration in chronic lymphocytic leukaemia

• CLL and metastatic tumour

• Aggressive NK cell leukaemia/lymphoma

• Aggressive NK cell lymphoma

• Flow cytometry in NK-lineage large granular lymphocytic leukaemia

• Trephine biopsy in Hodgkin's disease

• Bone marrow aspirate showing a Reed-Sternberg cell

• Foamy macrophages in ALL

• A typical basket-shaped smear cell in acute lymphoblastic leukaemia

• A small blast cell in the peripheral blood

• Symptomatic osteonecrosis of the knee in a patient with Hodgkin lymphoma

• Gross disfigurement secondary to extensive diffuse large B-cell lymphoma of the scalp

• Hyperhaploid multiple myeloma: very rare high-risk genetic subtype

• Intracardiac lymphoma on MRI imaging.

• Russell bodies in bone marrow of patient with lymphoplasmacytic lymphoma (1)

• Russell bodies in bone marrow of patient with lymphoplasmacytic lymphoma (2)

• Bi-nuclear lymphocyte

• AITL-RDD

• T-ALL relapsing as AML: the same but different

• Myeloid Malignancy

• Chronic myelomonocytic leukaemia

• Imatinib-induced myelodysplasia: clues in a peripheral blood film

• Leukaemia cutis

• Chronic myeloid leukaemia in accelerated phase

• Chronic myeloid leukaemia in chronic phase

• Hypopyon in blast crisis of chronic myelogenous leukaemia

• CML - Hypolobated small megakaryocyte and a pseudo-Gaucher cell

• Promyelocyte with a loose bundle of Auer rods acute promyelocytic leukaemia

• The retina in acute myeloid leukaemia

• Cytoplasmic RNP and basic protein content of blasts in AML

• ATRA-induced scrotal ulcers

• Fluorescence in situ hybridisation with ABL and RUNX1 probes (red) and ETV6 and BCR probes (green)

• Peripheral blood film in AML with t(9;11)(p22;q23)

• Blastic plasmacytoid dendritic cell neoplasm, clinical photograph

• Blood film in acute megakaryoblastic leukaemia

• Blood film in acute megakaryoblastic leukaemia (1)

• Acute basophilic leukaemia, bone marrow aspirate

• Clinical features of haematodermic CD4+CD56+ neoplasm (blastic plasmacytoid dendritic cell neoplasm)

• Haemophagocytosis

• Acute megakaryoblastic leukaemia, peripheral blood

• Acute myeloid leukaemia, blood film

• AML with Pseudo-Chédiak-Higashi granules

• BM aspirate in acute promyelocytic leukaemia

• Auer rods

• PAS-positivity in acute erythroid leukaemia

• Acute leukaemia with histiocytic differentiation (1)

• Acute myeloid leukaemia with histiocytic differentiation (2)

• Acute myeloid leukaemia with histiocytic differentiation (3)

• Acute myeloid leukaemia with histocytic differentiation (4)

• Acute myeloid leukaemia in a patient with b thalassaemia major, post-splenectomy (1)

• Acute myeloid leukaemia in a patient with b thalassaemia major, post-splenectomy

• Auer rods in a neutrophil following ATRA treatment of acute promyelocytic leukaemia (i)

• Auer rod in a neutrophil in a patient with acute promyelocytic leukaemia treated with ATRA (ii)

• Dysplastic neutrophil during ATRA treatment of acute promyelocytic leukaemia (i)

• Dysplastic neutrophil during ATRA treatment of acute promyelocytic leukaemia (ii)

• Unusually large granules in M1 AML (i)

• Unusually large granules in M1 AML (ii)

• Unusually large granules in M1 AML (iii)

• Unusually large granules in M1 AML (iv)

• Unusually large granules in M1 AML (v)

• Unusually large granules in M1 AML (vi)

• Unusually large granules in M1 AML (vii)

• Unusually large granules in M1 AML (viii)

• Peripheral blood film in acute monoblastic leukaemia (Jenner-Giemsa stain)

• Bone marrow aspirate film in acute monoblastic leukaemia (Jenner-Giemsa stain)

• Non-specific esterase (NSE) in acute monoblastic leukaemia (substrate: alpha naphthyl acetate esterase)

• Extracellular Auer rods: Can this be another clue to a diagnosis of acute promyelocytic leukaemia?

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (i)

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (ii)

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (iii); note long cytoplasmic tails of some cells

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (iv); note that several cells have long cytoplasmic tails

• Mitotic figure in a leukaemic cell in a patient with acute monocytic leukaemia with leukaemic cells resembling histiocytes (v)

• Cytological/cytochemical diagnosis of the variant form of acute promyelocytic leukaemia

• Morphological diagnosis of variant form of acute promyelocytic leukaemia, MGG (i)

• Morphological diagnosis of variant form of acute promyelocytic leukaemia, MGG (ii)

• Sudan black B stain in the variant form of acute promyelocytic leukaemia, SBB (i)

• Sudan black B stain in the variant form of acute promyelocytic leukaemia, SBB (ii)

• Sweet syndrome

• Blood film of a four-day-old baby with Down syndrome and transient abnormal myelopoiesis showing blast cells

• Blood film of a four-day-old baby with Down syndrome and transient abnormal myelopoiesis showing an immature cell of basophil lineage

• Blood film of a four-day-old baby with Down syndrome and transient abnormal myelopoiesis showing a nucleated red blood cell and a blast cell

• Dysplastic maturation during ATRA treatment of acute promyelocytic leukaemia

• Acute basophilic leukaemia, bone marrow, toluidine blue stain

• Acquired haemoglobin H disease

• Circulating dysplastic megakaryocyte in Down syndrome

• Hypolobulated megakaryocyte in 5q- syndrome

• Myelodysplastic syndrome, nuclear abnormalities

• Increased iron stores in refractory anaemia with excess of blasts

• Hypolobated megakaryocytes in refractory anaemia with excess of blasts

• Increased and dysplastic megakaryocytes in refractory anaemia with excess of blasts

• Dysplastic megakaryocytes, blast cells and increased proerythroblasts in RAEB

• A hypolobated megakaryocyte and immature cells, probably proerythroblasts, in a patient with RAEB

• Disorganised marrow in RAEB with increased immature cells, probably blast cells as well as proerythroblasts

• Myeloid neoplasm with FIP1L1-PDGFRA

• Intravascular haematopoiesis

• CT of chest showing extramedullary haemopoiesis

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, low power of peripheral blood film

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, high power view of blood film (1)

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, high power view of blood film (2)

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, high power view of blood film (3)

• Splenic histology in a patient with advanced primary myelofibrosis

• Essential thrombocythaemia - giant megakaryocyte

• Systemic mastocytosis, bone marrow aspirate

• Emperipolesis

• Emperipolesis (1)

• PB, primary myelofibrosis

• Bone marrow trephine biopsy in primary myelofibrosis, low power

• Bone marrow biopsy - Parrafin embedded section - Masson trichrome stain - PRIMARY MYELOFIBROSIS showing collagen fibrosis & osteomyelosclerosis

• Neonatal Langerhans cell histiocytosis(LCH) showing reactive haemophagocytosis in the bone marrow aspirate

• MYC overexpressing acute myeloid leukaemia with botryoid white cell nuclei as well as unusual cytoplasmic inclusions

• Blastic plasmacytoid dendritic cell leukaemia

• Acute promyelocytic leukaemia (APML) like morphology in acute myeloid leukaemis (AML) with myelodysplastic syndrome (MDS) related changes

• Emperipolesis in megakaryocyte (1)

• Marrow collagen fibrosis (MT stain) (1)

• Marrow collagen fibrosis (VG stain) (1)

• AML with t(8;21)

• The Rods

• AML with myelodysplasia-related changes

• Faggot cells acute pro-myelocytic leukaemia

• Paediatrics

• Blast cells in a neonate with Down's syndrome

• Leukaemic hypopyon

• A micromegakaryocyte in a child with refractory anaemia with excess of blasts-2 (RAEB2)

• Rhabdomyoblasts in the peripheral blood in rhabdomyosarcoma

• Hereditary xerocytosis, blood film

• ABO haemolytic disease of the newborn (HDN)

• Dystrophic nails in dyskeratosis congenita

• Osteopetrosis, trephine biopsy section

• Bilirubin crystals in neonatal hyperbilirubinaemia

• Platelets and Haemostasis

• Scurvy

• Platelet satellitism

• Normal platelet EM

• Grey platelet syndrome EM

• Intraretinal haemorrhage in autoimmune thrombocytopenic purpura

• Submacular haemorrhage in autoimmune thrombocytopenic purpura

• Macular retinal atrophy following submacular haemorrhage in autoimmune thrombocytopenic purpura

• A cord-like fragment of megakaryocyte cytoplasm in the bone marrow of a patient with immune thrombocytopenia

• Cord-like fragments of megakaryocyte cytoplasm in the bone marrow of a patient with immune thrombocytopenia

• Haemarthroses

• Knee showing haemarthrosis

• Patient with acquired factor VIII deficiency

• Suspected Bernard-Soulier syndrome, 4

• Suspected Bernard-Soulier syndrome, 1

• Suspected Bernard-Soulier syndrome, 2

• Suspected Bernard-Soulier syndrome, 3

• Osler-Weber-Rendu disease

• Haemorrhagic diathesis in a bulimia nervosa patient

• Haemophilic pseudocyst

• Red Cell Disorders

• Pyruvate kinase deficiency, post-splenectomy

• Erythroid islands: the crèches for the baby erythroids!

• An erythroid island

• Stomatocytes

• Sickle cell anaemia

• Coexisting sickle cell anaemia and G6PD deficiency

• Bone marrow fibrosis following bone marrow infarction in sickle cell anaemia

• Compound heterozygosity for haemoglobin S and haemoglobin C, peripheral blood film

• Compound heterozygosity for haemoglobin S and haemoglobin C, peripheral blood film, high power

• Compound heterozygosity for haemoglobin S and haemoglobin C, peripheral blood film, high power (1)

• Dyserythropoiesis in beta thalassaemia major

• Erythroid hyperplasia, basophilic stippling and two erythroblasts containing alpha chain inclusions in beta thalassaemia major

• Two alpha chain inclusions in an erythroblast in a patient with beta thalassaemia major

• Dyserythropoiesis and an erythroblast containing an alpha chain inclusion in beta thalassaemia major

• Hyperplastic erythropoiesis and a macrophage containing erythroblasts and cellular debris, a visual representation of ineffective erythropoiesis

• Iron-laden macrophage in beta thalassaemia major; there is cellular debris and refractile brown haemosiderin within the macrophage

• An erythroblast in beta thalassaemia major showing dyserythropoiesis (lobulated nucleus)

• An erythroblast in beta thalassaemia major showing a paranuclear alpha chain inclusion and dyserythropoiesis (lobulated nucleus)

• Two erythroblasts showing defective haemoglobinisation in beta thalassaemia major

• Ineffective erythropoiesis in beta thalassaemia major; a macrophage contains phagocytosed erythroblasts and golden-brown haemosiderin

• Haemoglobin H disease

• Dyserythropoiesis and Howell-Jolly bodies in defectively haemoglobinised cells. Normal transfused cells are also present

• Alpha chain inclusion in a circulating erythroblast

• Alpha chain inclusion surrounded by basophilic stippling in a circulating erythroblast

• Three erythroblasts containing alpha chain inclusions and small Howell-Jolly bodies

• Alpha chain inclusions, Howell-Jolly bodies and basophilic stippling

• Haemoglobin H inclusions

• Haemoglobin H inclusions (1)

• Acanthocytosis in abetalipoproteiaemia

• Dehydrated variant of hereditary stomatocytosis

• Haemoglobin H disease and G6PD deficiency (1)

• Haemoglobin H disease and G6PD deficiency (2)

• Haemoglobin H disease and G6PD deficiency (3)

• Pyruvate kinase deficiency, post-splenectomy (2)

• Pyruvate kinase deficiency, post-splenectomy (1)

• Coexistence of G6PD deficiency and sickle cell anaemia

• Combined vitamin B12 and folate deficiency

• Combined B12 and folate deficiency

• Marked hypochromia and microcytosis in severe iron deficiency anaemia

• A micronormoblast in the circulation in severe iron deficiency anaemia

• Elliptocytes (pencil cells) and marked hypochromia and microcytosis in severe iron deficiency anaemia

• Haemolytic uraemic syndrome, peripheral blood film

• Plasmodium malariae

• Malaria in a patient with Southeast Asian ovalocytosis

• Malaria in a patient with Southeast Asian ovalocytosis (1)

• Cabot's ring

• Microangiopathic haemolytic anaemia resulting from a viper bite

• Lantern cells after kidney transplant

• Lantern cells after kidney transplant 2

• Lantern cells after kidney transplant 3

• Asexual and sexual mature Plasmodium vivax sharing a red cell

• Transfusion Medicine

• Blood grouping, microtitre plate

• Extravasation of transfused blood

• Other organisations

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• Submit content

• Lectures and Videos

• Patient Perspective: The journey of Pain in Sickle Cell Disease

• Conference and events

• Events

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• Transfusion in Practice (1)

• Test Event - Do bot book (6)

• 15th Annual Sickle Cell and Thalassaemia Conference (2)

• The Royal Marsden Haemato-Oncology Virtual Study Day

• FRCPath Haemostasis and Thrombosis Training and Update (1)

• Lymphoma Management Course (1)

• BSH Haematology Taster Day

• Transfusion Updates 2021

• 2nd BSH Virtual CPD Talk

• Clinical Advances in Myeloma 2022

• BSBMTCT Education Day (1)

• UK MDS Forum Education Day (2)

• Current Thinking in Haematological Malignancies (3)

• UKFHD 52nd Academic Meeting

• Immunomodulation Updates: Advances in a COVID Era

• 24th London Lymphoma Forum

• Transfusion in Practice 2022

• UKMF Autumn Day (2)

• Myeloproliferative Neoplasms Advances Day 2021

• Clinical Haematology: The Essentials (1)

• Bone Marrow Trephine Biopsies

• Annual Scientific Meeting

• Promote your haematology event

• Event Terms and Conditions

• Crucible Prize

• Event FAQs

• 2nd BSH Return to Work Day

• 2021 BSH Lymphoma SIG Meeting: MDT Dilemmas

• BSH 2021 IMT Day

• Genomics

• Genomics Videos

• Genomics Resources

• Demonstration Videos

• Guidelines

• Guidelines

• Diagnosis and Management of Aplastic Anaemia

• Diagnosis of B12 and Folate Deficiency

• Diagnostic Pathway for the Investigation of Thrombocytosis

• Investigation and Management of Adults and Children Presenting with Thrombocytosis

• Laboratory Diagnosis of Functional Iron Deficiency

• Laboratory Diagnosis of Malaria

• Management of Acute Chest Syndrome in Sickle Cell Disease

• Modification of Diagnostic Criteria for Essential Thrombocythaemia

• Significant Haemoglobinopathies: Guidelines for Screening and Diagnosis

• Use of JAK Inhibitors in the Management of Myelofibrosis

• Use of Multicolour Flow Cytometry in the Diagnosis of Haematological Neoplasms

• Diagnosis and Investigation of AL Amyloidosis

• Diagnosis and Management of Acquired Coagulation Factor Inhibitor

• Diagnosis and Management of Respiratory Viral Infections in Patients with Haematological Malignancy

• Management of Diffuse Large B-cell Lymphoma

• First Line Management of Classical Hodgkin lymphoma

• Haematological Malignancies and ITU

• Investigation and Management of Nodular Lymphocyte Predominant Hodgkin Lymphoma

• Management of AL Amyloidosis

• Management of AML in Pregnancy

• Management of Mature T-cell and and NK-cell Neoplasms

• Management of Tumour Lysis Syndrome in Adults and Children with Haematological Malignancies

• Waldenstrom's Macroglobulinaemia

• Assessment of Bleeding Risk Prior to Surgery or Invasive Procedures

• Cancer and Thrombosis

• Diagnosis and Management of Heparin Induced Thrombocytopenia: Second Edition

• Diagnosis and Management of Rare Coagulation Disorders

• Diagnosis and Management of Thrombocytopenic Purpura and Other Thrombotic Microangiopathies

• Diagnosis and Management of Von Willebrand Disease

• Diagnosis and Treatment of Factor VIII and IX Inhibitors in Congenital Haemophilia

• Fibrinogen Assays

• Investigation and Management of Antiphospholipid Syndrome

• Investigation and Management of Venous Thrombosis at Unusual Sites

• Investigation, Management and Prevention of Venous Thrombosis in Children

• Laboratory Investigation of Heritable Disorders of Platelet Function

• Management of Bleeding in Patients on Antithrombotic Agents

• Measurement of Non-Coumarin Anticoagulants and their Effects on Tests of Haemostasis

• Oral Anticoagulation with Warfarin - 4th Edition

• Patient self-testing and self-management of oral anti-coagulants with vitamin K antagonists

• Testing for Heritable Thrombophilia

• Travel-Related Venous Thrombosis

• Use of Vena Cava Filters

• Administration of Blood Components

• Blood Grouping and Antibody Testing in Pregnancy

• Clinical Use of Apheresis Procedures

• Haematological Management of Major Haemorrhage

• Identification and Management of Pre-Operative Anaemia

• Investigation and Management of Acute Transfusion Reactions

• Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients

• Policies on Alternatives to Allogeneic Blood Transfusion: Predeposit Autologous Blood Donation

• Pre-Transfusion Compatibility Procedures in Blood Transfusion Laboratories

• Specification, Implementation and Management of Information Technology (IT) Systems in Hospital Transfusion Laboratories

• The Estimation of Fetomaternal Haemorrhage

• Transfusion for Fetuses, Neonates and Older Children

• Use of Anti-D Immunoglobin for the Prevention of Haemolytic Disease of the Fetus and Newborn

• Use of Platelet Transfusions

• Validation and Qualification, Including Change Control, for Hospital Transfusion Laboratories

• Investigation and Management of Eosinophilia

• The diagnosis and management of primary autoimmune haemolytic anaemia

• Management of Drug-Induced Immune and Secondary Autoimmune Haemolytic Anaemia

• Peri-Operative Management of Anticoagulation and Antiplatelet Therapy

• Red Cell Transfusion in Sickle Cell Disease Part l

• Red Cell Transfusion in Sickle Cell Disease Part II

• Investigation of Newly Detected M-Proteins and the Management of MGUS

• Diagnosis and Management of Disseminated Intravascular Coagulation (1)

• Screening and Management of Late and Long-term Consequences of Myeloma and its Treatment

• Use of Imaging in the management of patients with myeloma

• Management of Thrombotic and Haemostatic issues in Paediatric Malignancy

• Spectrum of fresh frozen plasma and cryoprecipitate products

• Diagnosis and therapy of genetic haemochromatosis (review and 2017 update)

• Investigation and management of a raised serum ferritin

• Guidelines for the use of hydroxycarbamide in children and adults with sickle cell disease

• Investigation and management of Transient Leukaemia of Down Syndrome

• Good practice paper on the diagnosis and investigation of patients with mantle cell lymphoma

• Guideline for the management of mantle cell lymphoma

• Treatment of chronic lymphocytic leukaemia

• The use of viscoelastic haemostatic assays in the management of major bleeding

• Diagnosis and management of primary central nervous system diffuse large B‐cell lymphoma

• Diagnosis and management of polycythaemia vera

• Management of specific situations in polycythaemia vera and secondary erythrocytosis

• The Prevention of glucocorticoid‐induced osteoporosis in patients with immune thrombocytopenia receiving steroids: Good Practice Paper

• The management of primary mediastinal B‐cell lymphoma: Good Practice Paper

• Point of Care in General Haematology

• UK guidelines on the management of iron deficiency in pregnancy

• Laboratory diagnosis of G6PD deficiency

• Red blood cell specifications for patients with hemoglobinopathies: a systematic review and guideline (ICTM Collaboration)

• The use of prophylactic factor replacement for children and adults with Haemophilia A and B

• Guideline on Laboratory aspects of assays used in haemostasis and thrombosis

• GPP The prevention of central nervous system relapse in diffuse large B‐cell lymphoma

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