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• New AML genes discovered

• 2017 Clinical Excellence Awards Round

• New genetic variants in blood groups discovered

• Dr Tim Littlewood first to be featured in BMJ’s new role model series

• Applications open to become the next BSH Student Representative

• Participate in the national Blood Transfusion and Blood Donation Survey

• RCP publish Future Hospital Programme report

• Applications invited for the position of Editor-in-Chief British Journal of Haematology

• Register now and save up to £150

• Abstract submissions for the BSH Annual Scientific Meeting 2018

• A HaemSTAR is born

• ASH 2017: British research highlights

• Drug combination offers hope for CLL patients

• Survey reveals current UK practice of managing Hodgkin’s lymphoma in older patients

• Applications open for L'Oreal-UNESCO Women in Science Awards

• Impact of BSH partnership recognised by national award

• Blood cell salvage may be unhelpful in caesarean

• Egyptian mummies reveal earliest known cancers

• Epigenetic signatures predict chemo result for CLL

• Iron overload drug could improve AML treatment

• Novel drug may hinder lymphoma growth

• Gene therapy treatment stops bleeding in haemophilia B patients

• Backing for gene therapy for ADA-SCID

• Novel target for CAR-T in multiple myeloma

• Tumour suppressor gene variants linked to secondary cancer in ALL

• Oxford haematology centre announced

• NHS scientist to develop sickle cell app

• Embryo cell map offers blood development clues

• GPs could “screen” for haematology cancer - MPs

• Hospital praised for myeloma care

• Molecular wrench 'melts away' leukaemia

• Increase in cancer cases prompts investment call

• Youth urged to make a date with donation

• Ibrutinib non-responders may benefit from combination therapy for CLL

• Digital digest - 2 February

• HSF1 blockers promising for multiple myeloma

• DNA repair and packaging genes linked to multiple myeloma risk

• BSH Blood Transfusion Guidelines used in NBTC Blood Components App

• Digital digest - 9 February

• Ageing immune system ‘key to cancer development risk’

• Hybrid-capture sequencing backed for lymphoid cancer

• Digital digest - 16 February

• Latest radiotherapy device will fine-tune bone marrow irradiation

• BSH member Dr Amit Sud awarded haematology research medal

• Progress predicted in haemoglobin disorder care

• Landmark CAR T-cell study results published

• Warning over anticoagulant use for atrial fibrillation in CKD

• Digital digest - 23 February

• Imaging tools reveals inner structure of red blood cells

• Celebrating Success: BSH member part of haematology department awarded Myeloma UK service award

• Promise for novel treatment in severe bleeding disorder

• Digital Digest - 2 March

• Age does not affect NHL survival after HCT

• STAT5 inhibitor could target oncogenic pathway in leukaemia

• Digital Digest - 9 March

• Increased heart failure risk for breast cancer and lymphoma patients

• Mixed-phenotype acute leukaemia patients benefit from less toxic therapy

• International women's day 2018: Meet some of our women members making a difference in haematology

• Digital Digest - 20 April

• Former BSH President Allan Victor Hoffbrand wins Sultan Bin Khalifa International Thalassemia Grand International Award

• Cardiovascular risks faced by child cancer survivors

• Clue to future ALL relapse

• Headway in development of lymphoma epigenetics therapeutics

• BSH becomes sponsor and partner of Health Volunteers Overseas

• Stored blood ‘less safe’ for some patients

• Warning as blood stocks stay low

• BSH announces Professor Simon Rule as new Vice President

• Scientists get stem cells through... the snow

• Rare disease patients need Europe - MPs

• Applications are now open for NHS England’s Clinical Entrepreneurs Programme

• New therapeutic targets for aggressive diffuse large B-cell lymphoma

• Warfarin alternatives effective for catheter ablation

• Anaemia risks maternal death

• Applications open for Chief Scientific Officer's Knowledge Transfer Partnership programme for leaders in healthcare science

• Annual Scientific Meeting - Join the social media campaign

• New VTE prevention guidance for over-16s

• Professor John Barrett MD appointed as Editor-in-Chief of British Journal of Haematology

• Genetic variation and biomarkers may help predict brain injury risk in paediatric ALL

• Gene fusion an early event in childhood leukaemia

• Chronic graft-versus-host disease gene regulation insight

• ‘Organic gene therapy’ approach suggested for red cell disorders

• New cancer drug class unveiled at Imperial

• Genetic alterations in multiple myeloma revealed

• Novel epigenetic link to blood cancer

• NHS genomics project “at risk” - MPs

• BSH announces Professor Cheng-Hock Toh as President

• Special Resolution to adopt updated articles

• Digital Digest - 11 May

• Bloodwise Highlights from the BSH Annual Scientific Meeting 2018

• NHS preparing to offer CAR-T therapy to patients

• ‘Young, Black and Stigmatised’ - Dr Sonia Wolf wins inaugural Crucible Prize

• Progress towards universal red cell source

• Meta-analysis reveals best treatments for post-partum haemorrhage

• The Aplastic Anaemia Trust are inviting grant applications as they launch new research strategy

• Genetic profiling of blood samples could help personalise multiple myeloma treatment

• Genomic analysis could help patients with DLBCL

• Type O blood ‘increases risk of death from trauma’

• World Thalassaemia Day – Time of new hope?

• BSH celebrating International Nurses Day 2018

• Introducing Professor Cheng-Hock Toh - BSH President's first message

• Step towards biomarker that predicts CAR T cell therapy response

• Senior haematologists have called on NHS England to reverse restrictions on using ibrutinib to treat relapsed chronic lymphocytic leukaemia

• CPD budget cuts affecting nursing skills - Royal College of Nursing

• Tablet hope for cancer-related VTE

• Genome sequencing allows improved blood transfusion matching

• Inflammatory signalling protein plays key role in AML

• Haemophilia survey highlights fears

• ALL gene-environment interaction points to hygiene factor

• How haemophilia nursing care is evolving

• European trial of new leukaemia drug pairing

• Reprogrammed cells could correct haemophilia B

• Genomic atlas of human plasma proteome unveiled

• BSH celebrate World Blood Donor Day 2018

• Chief Executive of the Sickle Cell Society is awarded an OBE in the Queen’s Birthday Honours.

• Bone marrow recreated in lab

• Gene editing of healthy cells offers prospect for CAR T treatment of AML

• World Sickle Cell Day - Dr Sonia Wolf Q&A

• What is Sickle Cell Disease (SCD)?

• Football key to blood donor recruitment

• New target to fight Fanconi anaemia

• GP urgent cancer referrals increase sharply

• Message from BSH President

• Lymphoma risk from myelofibrosis treatment

• Blood cancer therapy toxicity examined

• New drugs are improving survival times for patients with aggressive type of blood cancer

• BSH Celebrating 70 years of the NHS

• Sepsis research targets vascular leakage

• New drugs improve MCL patient survival times

• Leukaemia virus changes DNA packaging

• DOACs a safe alternative to warfarin

• EMA approves CAR T-cell therapies in milestone decision

• Former BSH President Dr Patrick Carrington interviewed on BBC 5 Live for NHS 70th Anniversary

• Contaminated blood inquiry truth promise

• Gene therapy hope for Hunter syndrome

• Genetic changes in blood predict AML risk

• Biomedical science day 2018 - Meet BSH Member Dr Maria Teresa Esposito

• AML cell study offers clues to super-drug improvement

• Off-target effects dash gene editing hopes

• Genetics of Xga blood group system uncovered

• Urine test useful for monoclonal gammopathy

• A message from BSH President, Professor Cheng-Hock Toh

• BSH President Professor Cheng-Hock Toh elected as Academic Vice President of the RCP

• Blood cancers taking longer to be diagnosed than other cancers

• Study informs on monosomy 7 genetics

• Fertility risk for sickle cell and chemotherapy patients

• Knife crime surge draws on blood stocks

• Urgent appeal for Ro blood donors

• BSH expanding Early Stage Research Start-Up programme

• Leukaemia patients spared repeat chemotherapy following NHS review

• Shot Report 2017 published

• Obituary - Dr S. Mitchell Lewis

• Former BSH President Dr Victor Hoffbrand receives Wallace H. Coulter Award for Lifetime Achievement in Haematology

• Computational platform developed for multiple myeloma treatment

• Simple blood test could detect Multiple Myeloma

• Novel targets for mixed lineage leukaemia

• Patients perplexed by blood cancer diagnosis

• Brexit blood product plans revealed

• Tributes to campaigner who became nurse

• Blood cancer patients could be denied life-saving CAR-T therapy

• A message from BSH President, Professor Cheng-Hock Toh - August 2018

• Blood cancer awareness - Meet BSH Member Graham Collins

• Celebrating NHS 70 and Haematology

• Blood test predicts lymphoma therapy success

• Enzymes may enable type O blood transformation

• CAR-T backed for NHS

• “Achilles’ heel” of anaplastic large-cell lymphoma identified

• Study discovers ten times more haematopoietic stem cells than previously thought

• Study reveals the impact on the brain of chemotherapy for acute lymphoblastic leukaemia

• Comment: Dr Maria Esposito on NHS decision to approve use of CAR T therapy

• AI to improve platelet supply

• Genomics focus: Meet BSH Member David Rees

• European collaboration for cancer research

• CAR-T therapy provisionally rejected for adult B-cell lymphoma

• Office Closure & Temporary Office Move

• ASM 2019: Call for abstract reviewers

• Changes to BSH Membership from 2019

• Immediate compression may reduce risk of long-term DVT complications

• A message from BSH President, Professor Cheng-Hock Toh - September 2018

• Paediatric radiotherapy guidance updated for new technologies

• Lung cancer drugs studied for leukaemia treatment

• BSH Student Essay Prize 2018

• Inquiry searches for undiagnosed blood contamination victims

• Apply for the 2019 Healthcare Science Awards

• Dan's Story: BSH member inspires patient to follow career in medicine

• CAR-T deal allows adult lymphoma treatment

• May’s SOS for cancer care

• Leukaemia UK launch 'Future of Haematology' Grants Programme

• Hope for fewer blood transfusions for myelodysplasia care

• World Thrombosis Day 2018 - Message from BSH President Professor Cheng-Hock Toh

• World Thrombosis Day: Meet BSH Member & Thrombosis expert Professor Beverley Hunt

• World Thrombosis Day: Thrombosis UK offer range of resources, grants and educational opportunities

• New prognostic tool provides “step change” in myeloproliferative neoplasm care

• Blood and organ donors from black communities needed

• Genetics-based prognostic tool developed for myelodysplastic syndrome

• NIHR-BSH Researcher of the Year Award scheme 2019

• Massive new AML dataset published

• BSH & Wiley renew partnership to publish British Journal of Haematology

• New technique revealed to help blood cells regenerate

• A message from BSH President, Professor Cheng-Hock Toh - October 2018

• Duvelisib hope for hard-to-treat CLL and SLL

• BSH Crucible Prize: Feature with 2018 winner Dr Sonia Wolf

• ‘Rethink’ needed for classification of VTE

• Relapsed AML returns in ‘stealth mode’

• National Pathology Week - Meet BSH Member Dr Sheila O'Connor

• Low-fat diet might benefit obese children with ALL

• Denosumab effective for osteoporosis in transfusion-dependent thalassaemia

• Chemotherapy and immunotherapy success in AML study

• Top 10 research priorities for living with and beyond cancer announced

• AML gene study brings personalised medicine one step closer

• Discount deal makes CAR-T available to young leukaemia patients

• Multiple myeloma drug hope

• A message from BSH President, Professor Cheng-Hock Toh - November 2018

• ‘Universal plasma’ filtration plans unveiled

• SCID study identifies factors influencing survival

• BSH to offer EHA Travel Grants

• CRISPR therapy feasible for foetal haemoglobin reactivation

• BSH Communications Committee Vacancy

• Fred Hutchinson researchers present latest on CAR-T cell therapy at ASH 2018

• Chance discovery could revolutionise platelet donations

• Paediatric CAR-T therapy begins in England

• BSH President Professor Cheng Hock Toh pays tribute to outgoing Editor of BJHaem, Professor Finbarr Cotter

• Sickle cell gene therapy success

• New tool to identify aggressive lymphomas

• Differences between paediatric and adult AML uncovered

• CAR T-cell therapy approved for more NHS treatment

• CRISPR accuracy breakthrough

• Terms & Conditions

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• Education

• Haematology images

• Bone marrow transplantation

• Fungal infection post-transplant

• Fungal infection post-transplant (3)

• A hierachy of conditioning regimes

• Autologous stem cell transplantation in myeloma or AL amyloidosis with severe renal impairment

• Autologous stem cell transplantation for amyloidosis: 1

• Autologous stem cell transplantation in AL amyloidosis: 2 

• Autologous stem cell transplantation for AL amyloidosis: 3

• Autologus stem cell transplantation for AL amyloidosis: 4

• Autologous stem cell transplantation for AL amyloidosis: 5

• Characteristic ultrasonography in intestinal graft-versus-host disease

• Air leak syndrome due to bronchiolitis obliterans post-bone marrow transplantation.

• Bronchiolitis obliterans post-bone marrow transplantation

• Neutropenic enterocolitis folllowing unrelated cord blood tranplantation, H& E stain

• Neutropenic enterocolitis following unrelated cord blood tranplantation, Gram stain

• Septic arthritis complicating transplantation

• Haemolytic-uraemic syndrome after stem cell transplantation

• Opportunistic infection following transplantation

• General

• Atypical lymphocyte in primary HIV infection

• Trephine biopsy in malignant melanoma

• Bone marrow aspirate in malignant melanoma

• Platelet aggregates, blood film

• Oxalosis, trephine biopsy section

• Intra-pelvic haemorrhage following trephine biopsy: CT scan of pelvis

• Paroxysmal nocturnal haemoglobinuria associated with haemophagocytic syndrome

• Gelatinous transformation

• Jordans' anomaly

• Biological mechanism of M-colonies and clusters formation: cleavage in a cluster of mouse bone marrow macrophages in agar culture

• Condensed nuclear chromosomes and mitochondrial DNP in mitosis (metaphase)

• Non-condensed chromosomes aligned at the metaphase plate as a marker of cleavage (arrested metaphase; prometaphase-like stage) in a model of early mouse embryogenesis.

• Cobra like macrophage in visceral leishmaniasis

• Bacilli in blood film

• Bacilli in blood film in pseudomonas septicemia

• Normal GM-colony

• Blast cell colony in mouse bone marrow agar culture

• Mouse eosinophil colony

• Compact part from myeloid (monocyte-macrophage) colony stained "in situ" in mouse bone marrow agar culture

• Differentiating monocyte/macrophage colony, stained "in situ" in bone marrow agar culture

• Intercellular relationships essential for stem cell development and in vitro colony formation

• Mitochondrial amplification is a biomarker in embryogenesis, leukaemogenesis and tumourigenesis

• Multiple mitochondria in normal and tumour cells

• Simultaneous staining, fluorescent labeling and UV-photolysis of stem cells' basic proteins

• Granulocyte-macrophage (GM) colony

• Avian leukaemia: biological mechanism of stem cell (blast) formation by budding

• Basic (cationic) proteins as cellular and sub-nuclear compartments of chromatin in actively proliferative (stem/blast-) cells can be visualised at the chromosome level in mitosis

• Protein-protein interactions in chromosomes

• Basic proteins/core histones could be visualised in mitotic nuclei

• Stromal changes following chemotherapy

• Congenital Pelger–Huët anomaly

• Cytological and cytochemical features of granulocytes and thrombocytes from the peripheral blood of cancer patients

• Oral haematoma

• Eosinophil from the peripheral blood film of chronic heroin addict

• Histoplasma in peripheral blood neutrophil

• Grade 0 reticulin

• Grade 1 reticulin

• Grade 2 reticulin

• Grade 3 reticulin

• Grade 4 reticulin, reticulin silver stain

• Grade 4 reticulin, Masson trichrome stain to show collagen

• Burkitt-like cytology in biphenotypic acute leukaemia.

• Burkitt-like cytology in biphenotypic acute leukaemia. (1)

• Extreme neutrophil vacuolisation in sepsis

• Striking monocyte vacuolisation in sepsis

• Toxic granulation and striking vacuolisation of neutrophils in sepsis

• Intramonocytic malarial pigment

• Histoplasmosis in bone marrow

• Leishmaniasis (i) : BM aspirate showing numerous large histiocytes forming clusters and having a syncytium like pattern (low power, Leishman stain)

• Leishmaniasis (ii): BM aspirate shows histiocytes filled with Leishman-Donovan bodies (Leishman stain, high power).

• Leishmaniasis (iii): BM aspirate showing haemophagocytosis by a histiocyte that is filled with Leishman-Donovan bodies (Leishman stain, high power)

• Mycobacterium avium intracellulare infection in a patient with AIDS

• Mycobacterium avium intracellulare (MAI) on routine H&E stain of a bone marrow section from a patient with AIDS

• Diagnosis of systemic lupus erythematosus by bone marrow cytology

• LE cells in incubated bone marrow

• SLE diagnosed from bone marrow

• Leucoerythroblastic blood film due to metastatic malignant melanoma in the bone marrow

• Circulating malignant melanoma cell, immunocytochemistry, APAAP technique, with hmb45

• Metastatic malignant melanoma in bone marrow, MGG stain

• Metastatic malignant melanoma in bone marrow trephine biopsy section, immunohistochemistry, APAAP technique, with hmb45

• Toxic Granuation and Döhle bodies in a patient with severe bacterial infection

• Mediastinal lymphadenopathy in infectious mononucleosis

• Bone marrow sarcoidosis in a patient with diffuse large B-cell lymphoma

• Visceral leishmaniasis (1)

• Visceral leishmaniasis (2)

• Visceral leishmaniasis (3)

• Visceral leishmaniasis (3) (1)

• Letterer-Siwe disease (1)

• Letterer-Siwe disease (2)

• Letterer-Siwe disease (3)

• Letterer-Siwe disease (4)

• Alveolar rhabdomyosarcoma infiltrating the bone marrow.

• Chest radiograph in Niemann-Pick disease

• Bone marrow aspirate in Niemann-Pick disease

• Leishmaniasis

• Leishman-Donovan bodies

• Haemophagocytosis in probable typhoid fever (1)

• Haemophagocytosis in probable typhoid fever (2)

• Haemophagocytosis in probable typhoid fever (3)

• Haemophagocytosis in probable typhoid fever.

• Probable granuloma in typhoid fever (1)

• Probable granuloma in typhoid fever (2)

• Toxic granulation and Döhle bodies

• Döhle bodies and toxic granulation

• Endothelial cells, low power

• Endothelial cells, high power

• Laboratory specimens turn green.

• Binucleated lymphocytes

• Cytoplasmic fragments mistaken for malaria parasites (1)

• Cytoplasmic fragments mistaken for malaria parasites (2)

• Cytoplasmic fragments mistaken for malaria parasites (3).

• A 'floater' on a slide of a trephine biopsy specimen.

• Another photograph of a "floater" on a slide of a trephine biopsy specimen.

• Haemosiderin in a plasma cell, May-Grünwald-Giemsa stain.

• Fat cell in the bone marrow, low power.

• Fat cell in the bone marrow, high power

• Gelatinous transformation of the bone marrow, low power

• Gelatinous transformation of the bone marrow, high power

• Tuberculous granulomas in a trephine biopsy section, low power

• Tuberculous granulomas in a trephine biopsy section, low power (ii)

• Tuberculous granulomas in a trephine biopsy section, high power.

• Neutrophil showing Alder-Reilly anomaly in a patient with a mucopolysaccharidosis

• Two neutrophils showing Alder-Reilly anomaly

• A lymphocyte showing abnormal granules in a patient with a mucopolysaccharidosis

• A monocyte showing abnormal granules in a patient with a mucopoysaccharidosis

• Toxic granulation and left shift induced by G-CSF

• Nuclear dysplasia and Döhle body formation induced by G-CSF

• Neutrophil vacuolation induced by G-CSF

• Multiple Döhle bodies and nuclear dysplasia induced by G-CSF

• Döhle body and vacuolation induced by G-CSF

• Left shift, toxic granulation, Döhle bodies and nuclear dysplasia induced by G-CSF

• Dysplastic neutrophil with ring-shaped nucleus following G-CSF therapy

• Alder-Reilly anomaly in a neutrophil

• Alder-Reilly anomaly in two neutrophils

• Gasser cell (lymphocyte with heavy granules)

• Monocyte with heavy granules and vacuoles as the result of a mucopolysaccharidosis

• Neutrophil showing Alder-Reilly anomaly

• Lymphocyte in mucopolysaccharidosis

• Monocyte in mucopolysaccharidosis

• Carcinoma cells infiltrating bone marrow with reactive fibrosis.

• Carcinoma cells infiltrating bone marrow (2) with reactive fibrosis

• Carcinoma cells in an imprint from a trephine biopsy section, low power.

• Carcinoma cells in an imprint from a trephine biopsy section, high power

• PAS-block positivity suspected from a Romonowsky-stained film

• Buffy coat film showing a clump of carcinoma cells

• LE cell

• Leishmaniasis: BM aspirate shows numerous large histiocytes (low power, Leishman stain) (1)

• Sea-blue histiocyte

• Sea-blue histiocytes

• Leishmaniasis, bone marrow aspirate

• Melanonychia striata secondary to hydroxycarbamide

• Chemotherapy-induced dysplasia

• Leishman-Donovan bodies in the bone marrow

• Leishmaniasis (1)

• Bone marrow aspirate, leishmaniasis

• Silicon breast implant rupture; an important but unrecognised cause of lymphadenopathy.

• Cohesive epithelioid macrophages in a bone marrow aspirate indicating the presence of granulomas (low power)

• Cohesive epithelioid macrophages in a bone marrow aspirate indicating the presence of granulomas (high power)

• Histology of bone marrow granuloma, H& E, low power

• Histology of bone marrow granuloma, H& E, high power

• Erythroid island

• A Mott cell

• Haemophagocytosis in the bone marrow aspirate of a young woman with coeliac disease.

• Haemophagocytic macrophage in coeliac disease

• Gaucher disease discovered during pregnancy

• Normal bone marrow film, Jenner-Giemsa with phosphate buffer at pH 6.6

• Monocytosis and enhanced monocytopoiesis in mice under in vivo influence of Crinum latifolium /L./ leave extracts

• Infection-related haemophagocytic lymphohistiocytosis (HLH) in a HIV stage 4 patient with Mycobacterium tuberculosis infection.

• Neuroblastoma with neuropil

• Bilateral Retro-orbital plasmacytomas occurring in a case of plasma cell leukaemia

• Abnormal nuclear chromatin condensation and distribution in granulocyte of cancer patient

• Unevenly condensed and distributed nuclear chromatin in "exhausted" peripheral blood lymphocytes of cancer patients

• Unevenly condensed and distributed nuclear chromatin in "exhausted" peripheral blood lymphocytes of cancer patients (1)

• Multiple mitochondria in "exhausted" peripheral blood lymphocytes of cancer patients

• Reduced quantity and uneven distribution of cytoplasmic ribonucleoproteins (RNP) in lymphocytes of cancer patients

• Emperipolesis in a patient with RAEB-2

• Dural biopsy in extranodal Rosai-Dorfman disease, which radiologically and histologically mimicked meningioma (H& E)

• Dural biopsy in extranodal Rosai-Dorfman disease, which radiologically and histologically mimicked meningioma (immunohistochemistry for S-100)

• A neutrophil with a drumstick in a healthy female

• Mitotic figure

• Fragmentation haemolysis secondary to sepsis in a 3-month-old female infant

• Plasmacytoid lymphocyte (Tϋrk cell)

• Congenital hip dislocation in Fanconi anaemia, X-ray

• Howell-Jolly body-like neutrophil inclusion (1)

• Howell-Jolly body-like neutrophil inclusion (2)

• Monocytes ‒ yes, but monotony ‒ never!

• Haemophagocytic lymphohistiocytosis

• Reactive myelofibrosis in metastatic tumour of unknown origin

• Reactive myelofibrosis (reticulin stain) in a metastatic tumour of unknown origin

• Vimentin stain of trephine biopsy section from a patient with a metastatic tumour of unknown origin with reactive myelofibrosis

• Plasmodium falciparum gametocyte (i)

• Plasmodium falciparum gametocyte (ii)

• Reactive haemophagocytosis in a bone marrow aspirate

• The stages of mitosis

• Mott cell

• MOTT CELL (1)

• Haemoglobin H disease

• Pancytopenia due to visceral leishmaniasis diagnosed on splenic biopsy

• Bone marrow metastatic involvement by penile squamous cell carcinoma

• Crystal Storing Histiocytosis Associated With Plasma Cell Myeloma

• The UK distinguished in a neutrophil

• Neutrophils changed appearance with a new heart

• LD bodies with marrow plasmacytosis

• Immunobiology

• Intercellular RNA/RNP interference (RNAi) and impaired mitochondrial recycling are of importance in malignancies

• The process of intercellular RNA/RNP interference (RNAi) is of importance in the immunobiology of malignancies

• Apoptosis pathways

• Erythroid island with central macrophage

• Perls' stain showing iron in macrophages

• Reactive lymphocytes in infection by Brucella spp (Brucellosis, also called undulant fever, or Malta fever)

• Large granular lymphocyte, blood film

• Uneven condensation and distribution of DNP in the nuclear chromatin of peripheral blood granulocytes as a diagnostic tool in malignancies

• Lymphoid malignancies

• Simultaneous diagnosis of precursor B-cell acute lymphoblastic leukaemia and chronic lymphocytic leukaemia, low power (1)

• Simultaneous diagnosis of precursor B-cell acute lymphoblastic leukaemia and chronic lymphocytic leukaemia, high power

• Neurolymphomatosis

• Anaplastic large cell lymphoma lymphoma

• Multiple myeloma 2, giant cell

• Multiple myeloma 3, Mott cell

• Multiple myeloma 4, Mott cells and Dutcher body

• Serum amyloid P scintogram before and after treatment

• Amyloid load shown by amyloid serum P scintogram

• Syncytial neoplastic cells in paediatric Hodgkin lymphoma

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, H& E, low power.

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, immunohistochemistry for CD30, low power.

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, H& E, high power, 1.

• Hodgkin lymphoma in the bone marrow, trephine biopsy section, H& E, high power, 2.

• Classical Reed-Sternberg cell in film of fine needle aspirate (Jenner-Giemsa stain)

• Lymph node biopsy in Hodgkin lymphoma

• Immunohistochemistry in Hodgkin's disease (Hodgkin lymphoma)

• Massive Hodgkin lymphoma

• Blood film of mantle cell lymphoma in evolution

• Paratrabecular infiltration in follicular lymphoma

• Recurrent non-Hodgkin lymphoma presenting as a right atrial mass and inferior vena cava thrombosis

• Sagittal sinus thrombosis following prophylactic intrathecal Methotrexate

• Diffuse large B-cell lymphoma

• Finger necrosis in cold agglutinin disease

• Type 1 cryoglobulinaemia in a patient with low grade non-Hodgkin lymphoma.

• Rouleaux formation in lymphoplasmacytic lymphoma

• Splenic marginal zone lymphoma with peripheral blood lymphocyte clusters.

• Diffuse large B-cell lymphoma in leukaemic phase

• Comparison of Ki67 positivity in mantle cell lymphoma (left) and in blastoid transformation (right)

• FDG-PET scan in cutaneous blastoid mantle cell lymphoma showing intense activity in a subcutaneous nodule.

• Cold agglutinin in non-Hodgkin lymphoma

• Follicular lymphoma in leukaemic phase

• Burkitt lymphoma

• Marginal zone lymphoma of bone: MRI appearance

• Marginal zone lymphoma of bone: histology

• Marginal zone lymphoma of bone: immunohistochemistry

• PET/CT showing neurolymphomatosis as the presenting feature in a relapsed diffuse large B-cell lymphoma

• Burkitt lymphoma (1)

• Recurrent non-Hodgkin lymphoma presenting as a right atrial mass

• Recurrent non-Hodgkin lymphoma presenting as a right atrial mass and inferior vena cava thrombosis (1)

• Bone marrow aspirate in primary diffuse large B-cell lymphoma of bone marrow (i)

• Bone marrow aspirate in primary bone marrow diffuse large B-cell lymphoma (ii)

• Hairy cell leukaemia, cell needs a haircut!

• Hairy cell leukaemia

• Echocardiogram showing diffuse large B-Cell lymphoma with cardiac involvement at diagnosis

• Anaplastic large cell lymphoma, ALK-positive, in pleural fluid

• Ziehl-Neelsen (ZN) stain demonstrating acid-fast bacilli, identified as M. chelonae, which were the cause of vascular-catheter-related bacteraemia

• Anaplastic Large T-Cell Lymphoma

• Primary cutaneous T-cell non-Hodgkin lymphoma on the shin completely healed following radiotherapy

• Skin infiltration in patient with adult Tcell leukaemia/lymphoma.

• Ringworm, Tinea corporis

• Primary cutaneous ALK-negative anaplastic large T-cell lymphoma

• Pathological fracture in adult T-cell leukaemia/lymphoma.

• Blood film in adult T-cell leukaemia/lymphoma

• Immunohistochemistry in subcutaneous panniculitis-like T-cell lymphoma.

• Perineural infiltration in T-prolymphocytic leukaemia

• Immunohistochemistry for CD3 in tissue biopsy in T-prolymphocytic leukaemia

• Sézary cells

• Anaplastic large cell lymphoma overspill into peripheral blood.

• Gastric involvement by adult T-cell leukaemia/lymphoma with co-existing Helicobacter pylori infection.

• Extranodal NK/T cell lymphoma of nasal type

• Leukaemic phase of extranodal NK/T cell lymphoma of nasal type, peripheral blood film

• Anaplastic large cell lymphoma

• Flow cytometry in T-lineage large granular lymphocyte leukaemia

• Peripheral blood in T-prolymphocytic leukaemia

• Co-expression of CD4 and CD8 in prolymphocytic leukaemia

• Hyperpigmentation and nodularity of skin in POEMS syndrome

• Circulating myeloma cell in a patient with refractory multiple myeloma.

• Extramedullary myeloma

• Multiple myeloma cells in cerebrospinal fluid

• Plasma cell endocytosis in multiple myeloma

• CT scan of the abdomen in myelomatous ascites

• Magnetic resonance imaging of the abdomen showing myelomatous ascites in a patient with plasma cell leukaemia (1)

• Magnetic resonance imaging showing myelomatous ascites in a patient presenting with plasma cell leukaemia (2)

• Myelomatous ascites in patient with previous asymptomatic myeloma, CD138

• Myelomatous ascites in a patient with previous asymptomatic myeloma, H& E

• Extramedullary plasmacytoma of lung, haematoxylin and eosin

• Flaming plasma cell in IgA myeloma

• Owl-eyed plasma cell

• Immunohistochemistry in myeloma

• Pathological fracture of the proximal third of the shaft of the left humerus in multiple myeloma.

• Cryoglobulinaemia

• Radiology showing multiple plasmacytomas

• CT scan of the pelvis in amyloidosis

• Plasmacytoma of the orbit in multiple myeloma, MRI scan (1)

• Plasmacytoma of the orbit in multiple myeloma, MRI scan (2)

• Plasmacytoma of orbit, histology following orbital biopsy: left, hematoxylin and eosin; right, immunohistochemistry for CD38

• Cryoglobulinaemia in multiple myeloma

• Bone marrow aspirate in multiple myeloma

• Histology and immunohistochemistry of unusual skin lesions in multiple myeloma

• Diplopia due to an intracerebral lesion in multiple myeloma

• Bone marrow in multiple myeloma (1)

• Bone marrow in multiple myeloma (2).

• Bone marrow in multiple myeloma (4): unusual cytoplasmic inclusions in myeloma cells

• Bone marrow in multiple myeloma (5): unusual cytoplasmic inclusions in myeloma cells.

• Myeloma cells with crystals (i)

• Myeloma cells with crystals (ii)

• Myeloma cells with crystals (iii)

• Auer-rod like crystals in macrophages in myeloma (i)

• Auer rod-like crystals in macrophages in multiple myeloma (ii)

• Biopsy of extramedullary plasmacytoma of the sphenoid sinus: left haematoxylin and eosin; right, immunohistochemistry for CD138

• Extramedullary plasmacytoma of the sphenoid sinus: T2 weighted MRI image

• Coexisting multiple myeloma and chronic lymphocytic leukaemia - coincidence or not?

• Bone marrow aspirate showing coexistence of myeloma cells and small lymphocytes with the phenotype of chronic lymphocytic leukaemia - more than coincidence?

• Cannibalistic myeloma cells

• Phagocytosis by myeloma cells

• Circulating plasma cells and rouleaux in plasma cell leukaemia

• Circulating plasma cells and rouleaux in plasma cell leukaemia (1)

• Myeloma cells including binucleate myeloma cell in plasma cell leukaemia

• Plasmablast in plasma cell leukaemia

• Auer-rod like inclusions in multiple myeloma

• Myeloma cells including a trinucleated cell containing Auer-rod-like inclusions

• Tissue biopsy section, multiple myeloma, haematoxylin and eosin

• Biopsy specimen from a lytic lesion of the right clavicle in a 60-year-old man.

• Circulating myeloma cells in secondary plasma cell leukaemia

• Giant myeloma cells

• Giant binucleate myeloma cell

• Giant trinucleate myeloma cell

• Giant quadranucleate myeloma cell

• Neoplastic pleural effusion in refractory multiple myeloma.

• Intracranial plasmacytoma causing bilateral sixth nerve palsy (1)

• Intracranial plasmacytoma causing bilateral sixth nerve palsy (2)

• Pleomorphic myeloma with multilobated plasma cells, May-Grünwald-Giemsa stain

• Multilobated myeloma cells, inset shows a clover-leaf nuclear formation.

• Pleomorphic multilobated NSE-positive myeloma cells

• Bisalbuminemia and a paraprotein band in a patient with multiple myeloma, demonstrated on an electrophoretic strip and scanning densitometry trace.

• Triclonal gammopathy

• Multinucleated tumour cell in multiple myeloma

• Multinucleated cell in multiple myeloma

• Multinucleated plasma cell in multiple myeloma

• Giant multinucleated tumour cells in multiple myeloma

• A giant multinucleated tumour cell in multiple myeloma

• Rouleaux formation and plasma cell - peripheral blood film of a patient with multiple myeloma

• Plasma cells in multiple myeloma - peripheral blood film

• Cytoplasmic inclusions in plasma cell - high power resolution

• Multiple myeloma 5, Dutcher body

• Multiple myeloma (1)

• Multiple myeloma (2)

• Multiple myeloma (3)

• Multiple myeloma (4)

• Multiple myeloma (5)

• Multiple Myeloma 1, Dutcher bodies

• CT scan showing middle cranial fossa plasmacytoma

• Magnetic resonance imaging showing middle cranial fossa plasmacytoma

• The role of cytokines

• Blood film in chronic lymphocytic leukemia, mixed cell type

• Paraneoplastic pemphigus

• Exaggerated insect bite reaction in a patient affected by chronic lymphocytic leukaemia (1)

• Exaggerated insect bite reaction in a patient affected by chronic lymphocytic leukaemia (2)

• Exaggerated insect bite reaction in a patient affected by chronic lymphocytic leukaemia (3)

• Chronic lymphocytic leukaemia, blood film

• CT scan showing a macronodular pattern of infiltration in chronic lymphocytic leukaemia

• Liver biopsy showing infiltration in chronic lymphocytic leukaemia, haematoxylin and eosin

• Immunohistochemistry of liver biopsy in chronic lymphocytic leukaemia

• CLL and metastatic tumour

• Ocular involvement in chronic lymphocytic leukaemia

• Gram-negative spinal abscess complicating treatment of chronic lymphocytic leukaemia (i)

• Gram-negative spinal abscess in chronic lymphocytic leukaemia (2): treatment

• Aggressive NK cell leukaemia/lymphoma

• Clinical prognostic factors in non-Hodgkin lymphoma

• Aggressive NK cell lymphoma

• Flow cytometry in NK-lineage large granular lymphocytic leukaemia

• POEMS presenting as arthritis

• Lymphangiogram showing lymph node involvement by Hodgkin's disease

• Trephine biopsy in Hodgkin's disease

• Bone marrow aspirate showing a Reed-Sternberg cell

• Hodgkin cells in a trephine biopsy section of bone marrow, H& E

• Foamy macrophages in ALL

• Anthracycline extravasation through a peripheral venous catheter

• A typical basket-shaped smear cell in acute lymphoblastic leukaemia

• A small blast cell in the peripheral blood

• Symptomatic osteonecrosis of the knee in a patient with Hodgkin lymphoma

• Gross disfigurement secondary to extensive diffuse large B-cell lymphoma of the scalp

• Scalp madd

• Myeloid malignancies

• Mitochondria enter the nucleus during myeloid cell malignancies and early embryogenesis

• Chronic myelomonocytic leukaemia

• Multiple mitochondria in atypical myeloid cell from the peripheral blood of Graffi tumour-bearing hamster

• Intracardiac lymphoma on MRI imaging.

• Sweet Syndrome (1)

• Imatinib-induced myelodysplasia: clues in a peripheral blood film

• Diagram of formation of the FIP1L1-PDGFRA fusion gene

• Cluster of undifferentiated myeloid cells in case of CML.

• CML - myeloid cell cluster in agar culture

• Biological mechanisms of GM-colonies and clusters formation - analogy to budding / cleavage / polar bodies formation in embryogenesis.

• Mitochondria detected within the nuclei of leukaemic (CML) cells

• Pleural effusion in imatinib-treated chronic myeloid leukaemia

• Leukaemia cutis

• Chronic myeloid leukaemia in accelerated phase

• Chronic myeloid leukaemia in chronic phase

• Hypopyon in blast crisis of chronic myelogenous leukaemia

• CML - Hypolobated small megakaryocyte and a pseudo-Gaucher cell

• Promyelocyte with a loose bundle of Auer rods acute promyelocytic leukaemia

• The retina in acute myeloid leukemia

• Cytoplasmic RNP and basic protein content of blasts in AML

• ATRA-induced scrotal ulcers

• Histology of ATRA-induced scrotal ulcers

• Fluorescence in situ hybridisation with ABL and RUNX1 probes (red) and ETV6 and BCR probes (green).

• Peripheral blood film in AML with t(9;11)(p22;q23)

• Blastic plasmacytoid dendritic cell neoplasm, clinical photograph

• Perivascular skin infiltration in transient abnormal myelopoiesis of Down syndrome

• Gingival hypertrophy

• Potential mechanisms of action of arsenic

• Second relapse of CD4+ CD56+ haematodermic neoplasm (blastic plasmacytoid dendritic cell neoplasm).

• Condensation and distribution of nuclear deoxyribonucleoproteins (DNP) in peripheral blood leucocytes in AML

• RNP in the blast cell from the peripheral blood of an AML patient

• Blood film in acute megakaryoblastic leukaemia

• Blood film in acute megakaryoblastic leukaemia (1)

• Acute basophilic leukaemia, peripheral blood film

• Acute basophilic leukaemia, bone marrow aspirate

• Acute basophilic leukaemia, flow cytometry

• Acute basophilic leukaemia, flow cytometry (1)

• Histology of CD4+ CD56+ haematodermic neoplasm (blastic plasmacytoid dendritic cell neoplasm).

• Clinical features of haematodermic CD4+CD56+ neoplasm (blastic plasmacytoid dendritic cell neoplasm).

• Haemophagocytosis

• M-FISH (Vysis Multi-target) Fluorescence in situ Hybridisation

• Acute megakaryoblastic leukaemia, peripheral blood

• Myeloid sarcoma of the testis, haematoxylin and eosin

• Myeloid sarcoma of the testis, immunohistochemistry with anti-CD68

• Acute myeloid leukaemia, blood film

• Pseudo-Chédiak-Higashi granules in AML

• AML with Pseudo-Chédiak-Higashi granules

• BM aspirate in acute promyelocytic leukaemia

• Auer rods

• PAS-positivity in acute erythroid leukaemia

• Acute leukaemia with histiocytic differentiation (1)

• Acute myeloid leukaemia with histiocytic differentiation (2)

• Acute myeloid leukaemia with histiocytic differentiation (3)

• Acute myeloid leukaemia with histocytic differentiation (4)

• Acute promyelocytic leukaemia

• Acute myeloid leukaemia in a patient with b thalassaemia major, post-splenectomy (1)

• Acute myeloid leukaemia in a patient with b thalassaemia major, post-splenectomy

• Auer rods in a neutrophil following ATRA treatment of acute promyelocytic leukaemia (i)

• Auer rod in a neutrophil in a patient with acute promyelocytic leukaemia treated with ATRA (ii)

• Dysplastic neutrophil during ATRA treatment of acute promyelocytic leukaemia (i)

• Dysplastic neutrophil during ATRA treatment of acute promyelocytic leukaemia (ii)

• Unusually large granules in M1 AML (i)

• Unusually large granules in M1 AML (ii)

• Unusually large granules in M1 AML (iii)

• Unusually large granules in M1 AML (iv).

• Unusually large granules in M1 AML (v)

• Unusually large granules in M1 AML (vi)

• Unusually large granules in M1 AML (vii)

• Unusually large granules in M1 AML (viii)

• Misleading lead: clinical photograph and skin scraping - leukaemia cutis or disseminated scabies?

• Pure erythroid island in acute myeloid leukaemia with myelodysplasia-related changes

• Peripheral blood film in acute monoblastic leukaemia (Jenner-Giemsa stain)

• Bone marrow aspirate film in acute monoblastic leukaemia (Jenner-Giemsa stain)

• Non-specific esterase (NSE) in acute monoblastic leukaemia (substrate: alpha naphthyl acetate esterase)

• Extracellular Auer rods: can this be another clue to a diagnosis of acute promyelocytic leukaemia?

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (i)

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (ii)

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (iii); note long cytoplasmic tails of some cells

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (iv); note that several cells have long cytoplasmic tails

• Mitotic figure in a leukaemic cell in a patient with acute monocytic leukaemia with leukaemic cells resembling histiocytes (v)

• AML and malaria

• Malaria and acute myeloid leukaemia

• Cytological/cytochemical diagnosis of the variant form of acute promyelocytic leukaemia.

• Morphological diagnosis of variant form of acute promyelocytic leukaemia, MGG (i).

• Morphological diagnosis of variant form of acute promyelocytic leukaemia, MGG (ii).

• Sudan black B stain in the variant form of acute promyelocytic leukaemia, SBB (i)

• Sudan black B stain in the variant form of acute promyelocytic leukaemia, SBB (ii)

• Co-occurrence of therapy-related acute myeloid leukaemia and relapsed multiple myeloma

• Sweet Syndrome

• Blood film of a 4-day-old baby with Down syndrome and transient abnormal myelopoiesis showing blast cells.

• Blood film of a 4-day-old baby with Down syndrome and transient abnormal myelopoiesis showing an immature cell of basophil lineage.

• Blood film of a 4-day-old baby with Down syndrome and transient abnormal myelopoiesis showing a nucleated red blood cell and a blast cell

• Pure acute erythroid leukaemia, bone marrow film (1)

• Pure acute erythroid leukaemia, bone marrow film

• Dysplastic maturation during ATRA treatment of acute promyelocytic leukaemia

• Acute basophilic leukaemia, bone marrow, toluidine blue stain

• Acquired haemoglobin H disease

• Circulating dysplastic megakaryocyte in Down syndrome

• Hypolobulated megakaryocyte in 5q-

• Myelodysplastic syndrome, nuclear abnormalities

• Alpha thalassaemia, myelodysplastic syndrome, blood film

• Increased iron stores in refractory anaemia with excess of blasts

• Hypolobated megakaryocytes in refractory anaemia with excess of blasts

• Increased and dysplastic megakaryocytes in refractory anaemia with excess of blasts

• Dysplastic megakaryocytes, blast cells and increased proerythroblasts in RAEB

• A hypolobated megakaryocyte and immature cells, probably proerythroblasts, in a patient with RAEB

• Disorganised marrow in RAEB with increased immature cells, probably blast cells as well as proerythroblasts

• Refractory anaemia with excess of blasts following treatment of multiple myeloma, bone marrow aspirate

• Atypical chronic myeloid leukaemia following myelofibrosis

• Myeloid neoplasm with FIP1L1-PDGFRA

• Intravascular haematopoiesis

• CT of chest showing extramedullary haemopoiesis

• Computed tomography showing main portal vein and splenic vein thrombosis in essential thrombocythaemia

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, low power of peripheral blood film

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, high power view of blood film (1)

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, high power view of blood film (2)

• Juvenile myelomonocytic leukaemia in beta thalassaemia major, high power view of blood film (3)

• Splenic histology in a patient with advanced primary myelofibrosis

• Essential thrombocythaemia - -giant megakaryocyte

• Systemic mastocytosis

• Bone disease in systemic mastocytosis

• Systemic mastocytosis, bone marrow aspirate

• Emperipolesis

• Emperipolesis (1)

• PB, primary myelofibrosis

• Bone marrow trephine biopsy in primary myelofibrosis, low power

• Bone marrow trephine biopsy, primary myelofibrosis, high power

• Chest radiograph in primary myelofibrosis

• Megakaryocytic sarcoma complicating primary myelofibrosis

• Bone marrow biopsy - Parrafin embedded section - Masson trichrome stain - PRIMARY MYELOFIBROSIS showing collagen fibrosis & osteomyelosclerosis

• Varicella-zoster pneumonia

• Acute transformation of chronic myelomonocytic leukaemia

• Chronic myelomonocytic leukaemia (1)

• A cluster of atypical monocytoid cells, growing in bone marrow agar culture of chronic myelomonocytic leukaemia (CMML)

• Neonatal Langerhans cell histiocytosis(LCH) showing reactive haemophagocytosis in the bone marrow aspirate.

• Peripheral blood basophils in cases of CML and cancer contain not only beta-metachromatic

• Acute monocytic leukaemia with leukaemic cells resembling histiocytes (3)

• MYC overexpressing acute myeloid leukaemia with botryoid white cell nuclei as well as unusual cytoplasmic inclusions

• Pediatrics

• Rhesus haemolytic disease of the newborn(HDN)

• Rhesus haemolytic disease of the newborn(HDN) (1)

• Blast Cells in a Neonate with Down's Syndrome

• Targeted therapy in infant ALL

• Overall survival in children with AML with Down's syndrome

• Leukaemic hypopyon

• A micromegakaryocyte in a child with refractory anaemia with excess of blasts-2 (RAEB2).

• Neutropenic enterocolitis following unrelated cord blood tranplantation in for therapy-related AML, H&E stain

• Neutropenic enterocolitis following unrelated cord blood transplantation in therapy-related AML, Gram stain

• Rhabdomyoblasts in the peripheral blood in rhabdomyosarcoma

• Event-free survival in AML in Down's syndrome

• Hereditary xerocytosis, blood film

• Blood film in paroxysmal cold haemoglobinuria

• Dyskeratosis congenita, family tree showing anticipation

• Dyskeratosis congenits, telomerase complex

• ABO haemolytic disease of the newborn (HDN)

• Rh haemolytic disease of the newborn (HDN)

• Dystrophic nails in dyskeratosis congenita

• Cerebral infarction in a 4-year-old girl with sickle cell anaemia

• Osteopetrosis, trephine biopsy section

• Carcinoma of the rectum in a patient with dyskeratosis congenita

• An interesting finding of Ebstain-Barr Virus infection in the bone marrow: Mott cell

• Platelets and hemostasis

• Scurvy

• Platelet aggregation studies in two patients with Bernard-Soulier syndrome, with 10 μmol/l ADP (left) and 1.5 μg/ml ristocetin (right); T = light transmission, t = time

• Platelet satellitism

• Diagrammatic illustration of the degradation of fibrinogen and non-cross-linked fibrin by plasmin

• Diagrammatic illustration of the degradation of cross-linked fibrin by plasmin.

• Normal platelet EM

• Grey Platelet Syndrome EM

• A ribbon-shaped platelet in a patient with breast cancer.

• Thrombosis of an inferior vena cava filter leading to fatal pulmonary embolus

• Aspirin-induced haemorrhagic diathesis

• Intraretinal haemorrhage in autoimmune thrombocytopenic purpura

• Submacular haemorrhage in autoimmune thrombocytopenic purpura.

• Macular retinal atrophy following submacular haemorrhage in autoimmune thrombocytopenic purpura.

• Thrombocytosis attributable to renal carcinoma

• Molecular mechanisms is autoimmune thrombocytopenic purpura

• Accuracy of the platelet count in thrombocytopenic patients

• A cord-like fragment of megakaryocyte cytoplasm in the bone marrow of a patient with immune thrombocytopenia

• Cord-like fragments of megakaryocyte cytoplasm in the bone marrow of a patient with immune thrombocytopenia

• CT scan showing carcinoma of left adrenal which led to acquired von Willebrand's disease

• Von Willebrand factor multimere pattern

• Haemarthroses

• Knee showing haemarthrosis

• Patient with acquired factor VIII deficiency

• Haemophilic pseudotumour

• Suspected Bernard-Soulier syndrome, 4.

• Suspected Bernard-Soulier syndrome, 1

• Suspected Bernard-Soulier syndrome, 2

• Suspected Bernard-Soulier syndrome, 3.

• Multiple intra-cranial haemorrhages in haemophilia

• Multiple intra-cranial haemorrhages in haemophilia (1)

• Sublingual haematoma in acquired haemophilia on CT scan

• Henoch-Schonlein purpura

• Osler-Weber-Rendu disease

• Haemorrhagic diathesis in a bulimia nervosa patient

• Haemophilic pseudocyst

• Unusual abdominal manifestations of catastrophic antiphospholipid syndrome

• Red cells

• The glycolytic pathway

• Vitamin B 12 absorption (i)

• Vitamin Bv 12 absorption (ii)

• Interferon-gamma stimulates erythroid colony formation

• Microspherocytosis resulting from severe burns

• Pyruvate kinase deficiency, post-splenectomy

• Erythroid islands: the crèches for the baby erythroids!

• An erythroid island

• Ring sideroblast

• Ring sideroblast (1)

• Normal Neonate HPLC Chromatogram

• Spuriously high WBC counts,and spurious lymphocytosis in a patient with abnormal haemoglobin

• Aetiology of iron deficiency anaemia

• Iron deficiency anaemia

• Low haemoglobin A 2 in iron deficiency anaemia

• Spherocytes

• Stomatocytes

• Sinus venous thrombosis on MR-angiography (arrow) as first manifestation of paroxysmal nocturnal haemoglobinuria

• Glycated haemoglobin S in a patient with diabetes mellitus

• Gallstones in a child with sickle cell anaemia

• MRI scan of the brain in a child with sickle cell anaemia

• Ulcer osteoma in sickle cell anaemia

• Sickle cell anaemia

• Chest radiograph of streptococcal pneumonia in sickle cell anaemia showing right upper lobe consolidation

• Coexisting sickle cell anaemia and G6PD deficiency

• Bone marrow fibrosis following bone marrow infarction in sickle cell anaemia

• Compound heterozygosity for haemoglobin S and haemoglobin C, peripheral blood film

• Compound heterozygosity for haemoglobin S and haemoglobin C, peripheral blood film, high power

• Compound heterozygosity for haemoglobin S and haemoglobin C, peripheral blood film, high power (1)

• Spontaneous migration of implantable venous access device (Port-A-Cath)  into ipsilateral internal jugular vein.

• Salmonella pyomyositis complicating sickle cell anaemia.

• Sickle cell anaemia complicated by salmonella pyomyositis.

• CT scan of chest of a patient with sickle cell anaemia and streptococcal pneumonia

• Red cell cytogram

• High performance liquid chromatography (HPLC) chromatogram in b thalassaemia heterozygosity showing an increased percentage of haemoglobin F and haemoglobin A 2

• An infant with β thalassaemia trait

• Diagnosis of β thalassaemia major from a bone marrow aspirate

• Dyserythropoiesis in beta thalassaemia major

• Erythroid hyperplasia, basophilic stippling and two erythroblasts containing alpha chain inclusions in beta thalassaemia major

• Two alpha chain inclusions in an erythroblast in a patient with beta thalassaemia major

• Dyserythropoiesis and an erythroblast containing an alpha chain inclusion in beta thalassaemia major

• Very low reticulocyte count in transfused beta thalassaemia major

• Hyperplastic erythropoiesis and a macrophage containing erythroblasts and cellular debris, a visual representation of ineffective erythropoiesis

• Iron-laden macrophage in beta thalassaemia major; there is cellular debris and refractile brown haemosiderin within the macrophage.

• An erythroblast in beta thalassaemia major showing dyserythropoiesis (lobulated nucleus)

• An erythroblast in beta thalassaemia major showing a paranuclear alpha chain inclusion and dyserythropoiesis (lobulated nucleus)

• Two erythroblasts showing defective haemoglobinisation in beta thalassaemia major

• Ineffective erythropoiesis in beta thalassaemia major; a macrophage contains phagocytosed erythroblasts and golden-brown haemosiderin

• Haemoglobin H disease

• Haemoglobin H disease (1)

• Alpha chain inclusions

• Beta thalassaemia major bone marrow aspirate

• Alpha chain inclusion

• Dyserythropoiesis and Howell-Jolly bodies in defectively haemoglobinised cells. Normal transfused cells are also present

• Alpha chain inclusion in a circulating erythroblast

• Alpha chain inclusion surrounded by basophilic stippling in a circulating erythroblast.

• Three erythroblasts containing alpha chain inclusions and small Howell-Jolly bodies

• Alpha chain inclusions, Howell-Jolly bodies and basophilic stippling

• Haemoglobin H inclusions

• Haemoglobin H inclusions (1)

• Cellulose acetate electrophoresis of haemoglobin

• Hemoglobin electrophoresis at alkaline pH

• The physiologic basis of Chuvash polycythaemia

• Angioid streaks in type I congenital dyserythropoietic anaemia, shown by fluorescein angiography

• Pyrimidine 5' nucleotidase deficiency

• Fanconi facies

• Ovalocytes and elliptocytes

• G6PD Deficiency

• Hereditary elliptocytosis as an incidental discovery in a two-year-and-a half boy

• Acanthocytosis in abetalipoproteiaemia

• Peripheral blood film in type I congenital dyserythropoietic anaemia

• Bone marrow aspirate in Type I congenital dyserythropoietic anaemia

• Dehydrated variant of hereditary stomatocytosis

• Haemoglobin H disease and G6PD deficiency (1)

• Haemoglobin H disease and G6PD deficiency (2)

• Haemoglobin H disease and G6PD deficiency (3)

• Pyruvate kinase deficiency, post-splenectomy (2)

• Pyruvate kinase deficiency, post-splenectomy (1)

• Hereditary spherocytosis. The red cells stain heavily and lack central pallor.

• Coexistence of G6PD deficiency and sickle cell anaemia.

• Ring sideroblast (2)

• Paroxysmal noctural haemoglobinuria, flow cytometry

• Simultaneous anisocytosis of red blood cells and platelets in chronic heroin addicts

• Combined vitamin B12 and folate deficiency

• Combined B12 and folate deficiency

• Plasmodium malariae - Rosette/daisy-head schizont

• Marked hypochromia and microcytosis in severe iron deficiency anaemia

• A micronormoblast in the circulation in severe iron deficiency anaemia

• Elliptocytes (pencil cells) and marked hypochromia and microcytosis in severe iron deficiency anaemia

• Iron deficiency anaemia, blood film

• Haemolytic uraemic syndrome, peripheral blood film

• Haemolytic uraemic syndrome, peripheral blood film, high power

• Urinary haemosiderin

• Paroxysmal nocturnal haemoglobinuria

• Megaloblastic anaemia mimicking microangiopathic haemolytic anaemia

• Plasmodium malariae

• Malaria in a patient with Southeast Asian ovalocytosis

• Malaria in a patient with Southeast Asian ovalocytosis (1)

• Cabot's ring

• Microangiopathic haemolytic anaemia resulting from a viper bite

• Vitamin B2 absorption in the ileum

• Pigmentation of the nails in megaloblastic anaemia

• Melanodermia and vitamin B12 deficiency

• Subacute combined degeneration of the spinal cord

• Acanthocytosis in anorexia nervosa

• Red cell histogram in mechanical red cell fragmentation

• Reticulocyte channel scattergram in mechanical red cell fragmentation

• Autoimmune haemolytic anaemia, blood film

• Compound heterozygosity for haemoglobin S and haemoglobin D-Punjab (D-Los Angeles). HPLC Chromatogram using Bio-Rad Variant II "β-thalassemia short program".

• Lantern Cells After Kidney Transplant

• Lantern Cells After Kidney Transplant 2

• Lantern Cells After Kidney Transplant 3

• Asexual and sexual mature Plasmodium vivax sharing a red cell

• Transfusion science

• Is transfusion of non-WBC-depleted red cells associated with an increased risk of post-operative infection? (i)

• Is transfusion of non-WBC-depleted red cells associated with an increased risk of post-operative infection? (ii)

• Is transfusion of non-WBC-depleted red cells associated with an increased risk of post-operative infection? (iii)

• ABO hybrid genes

• MNS hybrid genes

• Rh hybrid genes

• Granulocyte antigens

• Transfusion practice

• Preparation of red cells for transfusion

• Plateletpheresis

• Triggers for platelet transfusion and accuracy of platelet count

• Preparation of fresh frozen plasma

• Transfusion-Related Acute Lung Injury (TRALI)

• Red cell antibody screening, microcolumn

• Blood grouping, microtitre plate

• The process to ensure transfusion safety.

• A bar-code system to maintain patient safety (1)

• A bar-code system to maintain patient safety (2)

• Serious hazards of transfusion

• Bedside use of a barcode system

• Extravasation of transfused blood

• Other organisations

• Students

• Submit content

• Lectures and Videos

• Conference and events

• Events

• Laboratory Haematology & Morphology Course

• FRCPath1 Revision Course

• BSH Making Sense of Haematology - A Primer for Medical Students and Junior Doctors

• FRCPath 2 Mock Revision Course

• New Frontiers in Coagulation Medicine

• MDS 2019 - 15th International Symposium on Myelodysplastic Syndromes

• The London Haematopathology Course

• POST ISTH & ASH Headlines 2019 non-malignant haematology update day Manchester

• POST ASH Significant Highlights - Bristol

• POST ASH Significant Highlights - Manchester

• POST ASH Significant Highlights - London

• FRCPath Exam Study Day for Haematology Trainees

• The 26th International Congress on Thrombosis

• Manchester Blood Coagulation Course Spring 2019

• BSH Trainees Day

• The Oxford Haematology in Obstetrics Postgraduate Course

• 16th National Post ASH Update Educational Seminar

• BSH Obstetric Haematology November Meeting 2018

• BSH Paediatric Symposium

• FRCPath Intensive Practical Course in Haemostasis

• Laboratory Haematology: preparing for the FRCPath Exam

• Bloodwise Advanced Communication Masterclass: supporting haemato-oncology nursing practice

• 8th InterAmerican Oncology Conference 'Current Status and Future of Anti-Cancer Therapies'

• A User Guide to Cancer Immunotherapy

• Targeted Treatments for Haematological Cancers

• Annual Scientific Meeting

• Promote your haematology event

• Event Terms and Conditions

• Guidelines

• Guidelines

• Diagnosis and Management of Aplastic Anaemia

• Diagnosis of B12 and Folate Deficiency

• Diagnosis, Investigation and Management of Polycythaemia/Erythrocytosis

• Diagnostic Pathway for the Investigation of Thrombocytosis

• Investigation and Management of Adults and Children Presenting with Thrombocytosis

• Laboratory Diagnosis of Functional Iron Deficiency

• Laboratory Diagnosis of Malaria

• Management of Acute Chest Syndrome in Sickle Cell Disease

• Management of Iron Deficiency in Pregnancy

• Modification of Diagnostic Criteria for Essential Thrombocythaemia

• Point-of-Care Testing: Haematology

• Significant Haemoglobinopathies: Guidelines for Screening and Diagnosis

• Use of JAK Inhibitors in the Management of Myelofibrosis

• Use of Multicolour Flow Cytometry in the Diagnosis of Haematological Neoplasms

• Diagnosis and Investigation of AL Amyloidosis

• Diagnosis and Management of Acquired Coagulation Factor Inhibitor

• Diagnosis and Management of Adult Myelodysplastic Syndromes

• Diagnosis and Management of Respiratory Viral Infections in Patients with Haematological Malignancy

• Diagnosis and Management of Solitary Plasmacytoma of Bone, Extramedullary Plasmacytoma and Multiple Solitary Plasmacytomas

• Diagnosis and Therapy of Hairy Cell Leukaemia

• Diagnosis of Post-Transplant Lymphoproliferative Disorders

• Management of Diffuse Large B-cell Lymphoma

• First Line Management of Classical Hodgkin lymphoma

• Haematological Malignancies and ITU

• Investigation and Management of Nodular Lymphocyte Predominant Hodgkin Lymphoma

• Management of AL Amyloidosis

• Management of AML in Pregnancy

• Management of Mature T-cell and and NK-cell Neoplasms

• Management of Post-Transplant Lymphproliferative Disorder

• Management of Primary Resistant and Relapsed Classical Hodgkin Lymphoma

• Management of Tumour Lysis Syndrome in Adults and Children with Haematological Malignancies

• Waldenstrom's Macroglobulinaemia

• Assessment of Bleeding Risk Prior to Surgery or Invasive Procedures

• Cancer and Thrombosis

• Diagnosis and Management of Heparin Induced Thrombocytopenia: Second Edition

• Diagnosis and Management of Rare Coagulation Disorders

• Diagnosis and Management of Thrombocytopenic Purpura and Other Thrombotic Microangiopathies

• Diagnosis and Management of Von Willebrand Disease

• Diagnosis and Treatment of Factor VIII and IX Inhibitors in Congenital Haemophilia

• Fibrinogen Assays

• Investigation and Management of Antiphospholipid Syndrome

• Investigation and Management of Venous Thrombosis at Unusual Sites

• Investigation, Management and Prevention of Venous Thrombosis in Children

• Laboratory Aspects of Assays Used in Haemostasis and Thrombosis

• Laboratory Investigation of Heritable Disorders of Platelet Function

• Management of Bleeding in Patients on Antithrombotic Agents

• Management of Haemophilia in the Fetus and Neonate

• Measurement of Non-Coumarin Anticoagulants and their Effects on Tests of Haemostasis

• Oral Anticoagulation with Warfarin - 4th Edition

• Patient self-testing and self-management of oral anti-coagulants with vitamin K antagonists

• Selection and Use of Therapeutic Products to Treat Haemophilia and Other Hereditary Bleeding Disorders

• Testing for Heritable Thrombophilia

• Travel-Related Venous Thrombosis

• Use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A

• Use of Vena Cava Filters

• Administration of Blood Components

• Blood Grouping and Antibody Testing in Pregnancy

• Clinical Use of Apheresis Procedures

• Haematological Management of Major Haemorrhage

• Identification and Management of Pre-Operative Anaemia

• Investigation and Management of Acute Transfusion Reactions

• Management of Anaemia and Red Cell Transfusion in Adult Critically Ill Patients

• Policies on Alternatives to Allogeneic Blood Transfusion: Predeposit Autologous Blood Donation

• Pre-Transfusion Compatibility Procedures in Blood Transfusion Laboratories

• Specification, Implementation and Management of Information Technology (IT) Systems in Hospital Transfusion Laboratories

• The Estimation of Fetomaternal Haemorrhage

• Transfusion for Fetuses, Neonates and Older Children

• Use of Anti-D Immunoglobin for the Prevention of Haemolytic Disease of the Fetus and Newborn

• Use of Irradiated Blood Components

• Use of Platelet Transfusions

• Validation and Qualification, Including Change Control, for Hospital Transfusion Laboratories

• Investigation and Management of Eosinophilia

• The diagnosis and management of primary autoimmune haemolytic anaemia

• Management of Drug-Induced Immune and Secondary Autoimmune Haemolytic Anaemia

• Peri-Operative Management of Anticoagulation and Antiplatelet Therapy

• Red Cell Transfusion in Sickle Cell Disease Part l

• Red Cell Transfusion in Sickle Cell Disease Part II

• Investigation of Newly Detected M-Proteins and the Management of MGUS

• Diagnosis and Management of Disseminated Intravascular Coagulation (1)

• Screening and Management of Late and Long-term Consequences of Myeloma and its Treatment

• The Investigation and Management of Follicular Lymphoma

• Use of Imaging in the management of patients with myeloma

• Management of Thrombotic and Haemostatic issues in Paediatric Malignancy

• Spectrum of fresh frozen plasma and cryoprecipitate products

• Diagnosis and therapy of genetic haemochromatosis (review and 2017 update)

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• Treatment of chronic lymphocytic leukaemia

• The use of viscoelastic haemostatic assays in the management of major bleeding

• Diagnosis and management of primary central nervous system diffuse large B‐cell lymphoma

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• Management of specific situations in polycythaemia vera and secondary erythrocytosis

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