Chinese scientists have reported the discovery of a new immune checkpoint, which might help in the treatment of blood cancers.
Laboratory studies suggest that blocking the CD300A protein triggers a “significant boost” in the activity of natural killer (NK) cells against cancer cells, according to the researchers from the University of Science and Technology of China.
Reporting in Cancer Biology & Medicine, the researchers say the CD300A protein is a type 1 transmembrane protein with immunoreceptor tyrosine based inhibitory motifs. The protein aids the defence of cancer cells against NK cells by interacting with phosphatidylserine, a molecule sometimes found on the surface of cancer cells, the researchers report.
The researchers say t...
2 days ago
