Scientists have discovered some of the ways in which genetic drivers can predict poor responses to CAR-T therapy in large B cell lymphomas.
Dr Jonathan Schatz and his team at the University of Miami, USA, used whole genome sequencing to identify mutations that appear to make B-cell lymphomas resistant to CAR-T immunotherapies.
Findings were published in the journal Blood recently. The team focused on CAR (chimeric antigen receptor) T cells – immune cells taken from the patient and engineered to target the CD19 receptor on lymphoma cells.
Although these treatments are highly successful, some patients develop resistance to the treatment.
The work looked beyond previously discovered mechanisms of CAR-T resistance, such as mu...
5 days ago
Scientists have discovered some of the ways in which genetic drivers can predict poor responses to CAR-T therapy in large B cell lymphomas.
Dr Jonathan Schatz and his team at the University of Miami, USA, used whole genome sequenci...
5 days ago
People with long COVID may face an increased risk of abnormal blood clotting, according to the first study to look at the link between abnormal blood clotting tests and reduced exercise capacity.
Researchers from University College...
5 days ago