Last Review Date: Monday, 8 December 2025

The focus of this good practice paper (GPP) is to provide practical guidance on patient assessment, treatment administration and toxicity management relating to treatment with anti-CD3 × CD20 bispecific antibodies (BsAb) as currently approved by the Medicines and Healthcare products Regulatory Agency (MHRA) and/or European Medicines Agency (EMA). The role of these antibodies in the treatment pathway of large B-cell lymphoma (LBCL) or follicular lymphoma (FL) is beyond the scope of this paper, but the former is covered in the BSH Guideline for the management of relapsed or refractory (R/R) LBCL.

Podcast: Clinical management of bispecific antibody therapy for lymphoma - Length: 35:53
Podcast on the Clinical management of bispecific antibody therapy for lymphoma Good Practice Paper, presented by Dr Matthew Wilson, Dr Sridhar Chaganti and Dr Wendy Osborne.

Declaration of Interests

The BSH paid the expenses incurred during the writing of this good practice paper. All authors have made a declaration of interests to the BSH and Task Force Chairs which may be viewed on request.