The objective of this guideline is to provide healthcare professionals with guidance on the investigation and management of patients with Transient Leukaemia of Down Syndrome (TL‐DS). Individual patient circumstances may dictate an alternative approach. This is the first BSH guideline on this topic and is in date at time of publication.

Declaration of Interests

The BSH paid the expenses incurred during the writing of this guidance. None of the authors had conflicts of interest to declare. All authors have made a declaration of interests to the BSH and Task Force Chairs which may be viewed on request.